单位：[1]Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing 100050, China临床科室国家中心消化分中心消化内科首都医科大学附属北京友谊医院
Tumors are surrounded by complex environmental components, including blood and lymph vessels, fibroblasts, endothelial cells, immune cells, cytokines, extracellular vesicles, and extracellular matrix. All the stromal components together with the tumor cells form the tumor microenvironment (TME). In addition, extracellular physical and chemical factors, including extracellular pH, hypoxia, elevated interstitial fluid pressure, and fibrosis, are closely associated with tumor progression, metastasis, immunosuppression, and drug resistance. Cellular and extracellular components in TME contribute to nearly all procedures of carcinogenesis. By summarizing the recent work in this field, we make a comprehensive review on the role of cellular and extracellular components in the process of carcinogenesis and their potential application in early diagnosis of cancer. We hope that a systematic review of the diverse aspects of TME will help both research scientists and clinicians in this field.
第一作者单位：[1]Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing 100050, China
通讯作者：
推荐引用方式(GB/T 7714)：
Wei Rui,Liu Si,Zhang Shutian,et al.Cellular and Extracellular Components in Tumor Microenvironment and Their Application in Early Diagnosis of Cancers[J].ANALYTICAL CELLULAR PATHOLOGY.2020,2020:doi:10.1155/2020/6283796.
APA：
Wei, Rui,Liu, Si,Zhang, Shutian,Min, Li&Zhu, Shengtao.(2020).Cellular and Extracellular Components in Tumor Microenvironment and Their Application in Early Diagnosis of Cancers.ANALYTICAL CELLULAR PATHOLOGY,2020,
MLA：
Wei, Rui,et al."Cellular and Extracellular Components in Tumor Microenvironment and Their Application in Early Diagnosis of Cancers".ANALYTICAL CELLULAR PATHOLOGY 2020.(2020)
