单位：[1]Department of Hematology, The Second Affiliated Hospital of Guangzhou Medical University, 510260 Guangzhou, China[2]Translational Medicine Center, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital of Guangzhou Medical University, 510260 Guangzhou, China[3]Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands[4]Department of Biomedical Sciences, University of Sassari, Sassari, Italy[5]Translational Medicine Center, Huaihe Hospital of Henan University, 475000 Kaifeng, China[6]Department of Hematology, Huaihe Hospital of Henan University, 475000 Kaifeng, China[7]Department of Operations and Information Management, China- Japan Friendship Hospital, 100029 Beijing, China[8]Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, 310058 Hangzhou, China[9]Department of Biomedical Engineering, Chinese PLA General Hospital, 100853 Beijing, China
Acute myeloid leukemia (AML) is a malignant disease of myeloid hematopoietic stem or progenitor cells characterized by abnormal proliferation of primary and immature myeloid cells in bone marrow and peripheral blood. Gene mutation and expression profiles can be used as prognosis predictors for different prognostic subgroups. Secretory carrier-associated membrane proteins (SCAMPs) are a multigenic family with five members and act as cell surface vectors in the post-Golgi recycling pathways in mammals. Nevertheless, the prognostic and clinical influence of SCAMP family has hardly ever been illustrated in AML. In our study, expression patterns of SCAMP family (SCAMP1-5) were analyzed in 155 AML patients which were extracted from the Cancer Genome Atlas database. In chemotherapy, only subgroup, higher SCAMP1 level was significantly associated with longer EFS and OS (all P = 0.002), and SCAMP1 was confirmed to be an independent favorable factor in un-transplanted patients by Multivariate analysis (all P < 0.05). Nevertheless, in the allogeneic hematopoietic stem cell transplantation (allo-HSCT) treatment subgroup, none of the SCAMP genes had any effect on the clinical survival. Our study found that high expression level of SCAMP1 is a favorable prognostic factor in AML, but allo-HSCT may neutralize its prognostic effect.
基金：
Xinjiang Joint Fund of National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [U1903117]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81600089, 81500118, 61501519]
第一作者单位：[1]Department of Hematology, The Second Affiliated Hospital of Guangzhou Medical University, 510260 Guangzhou, China[2]Translational Medicine Center, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital of Guangzhou Medical University, 510260 Guangzhou, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Hematology, The Second Affiliated Hospital of Guangzhou Medical University, 510260 Guangzhou, China[2]Translational Medicine Center, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital of Guangzhou Medical University, 510260 Guangzhou, China[5]Translational Medicine Center, Huaihe Hospital of Henan University, 475000 Kaifeng, China[6]Department of Hematology, Huaihe Hospital of Henan University, 475000 Kaifeng, China
推荐引用方式(GB/T 7714)：
Tingting Qian,Zhiheng Cheng,Liang Quan,et al.Prognostic role of SCAMP family in acute myeloid leukemia[J].PHARMACOGENOMICS JOURNAL.2020,20(4):595-600.doi:10.1038/s41397-020-0149-2.
APA：
Tingting Qian,Zhiheng Cheng,Liang Quan,Tiansheng Zeng,Longzhen Cui...&Lin Fu.(2020).Prognostic role of SCAMP family in acute myeloid leukemia.PHARMACOGENOMICS JOURNAL,20,(4)
MLA：
Tingting Qian,et al."Prognostic role of SCAMP family in acute myeloid leukemia".PHARMACOGENOMICS JOURNAL 20..4(2020):595-600
