单位：[1]Department of Gastroenterology, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, P. R. China临床科室国家中心消化分中心消化内科首都医科大学附属北京友谊医院
Esophageal squamous cell carcinoma (ESCC) is one of the most common and aggressive malignancies in China. Cancer-associated fibroblasts (CAFs) can actively communicate with and stimulate tumor cells, thereby contributing to the development and progression of tumors. Yet, whether CAFs-derived exosomes have a role in the progression of ESCC is largely unknown. Here, we find that Sonic Hedgehog (SHH) is highly expressed in CAFs lysis solution, conditioned medium of cultured CAFs (CAF-CM) and CAFs-derived exosomes, and esophageal cancer cell lines educated by CAF-CM and CAFs-derived exosomes can improve their growth and migration abilities in vitro and in vivo. Besides, those effects can be partly neutralized by cyclopamine, inhibitor of the Hedgehog signaling pathway. Thus, our research elucidates the crucial role of CAFs-derived exosomes in the growth and progression of ESCC, and may open up new avenues in the treatment of ESCC.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81702314, 81570507]; Funding Program for Excellent Talents of Beijing [2017000021469G212]; Beijing Municipal Administration of Hospitals' Youth Program [QML20180108]; National Key Research and Development Program of China [2017YFC0113600]
第一作者单位：[1]Department of Gastroenterology, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, P. R. China
通讯作者：
通讯机构：[1]Department of Gastroenterology, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, P. R. China[*1]Department of Gastroenterology, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P. R. China.
推荐引用方式(GB/T 7714)：
Guiping Zhao,Hengcun Li,Qingdong Guo,et al.Exosomal Sonic Hedgehog derived from cancer-associated fibroblasts promotes proliferation and migration of esophageal squamous cell carcinoma[J].CANCER MEDICINE.2020,9(7):2500-2513.doi:10.1002/cam4.2873.
APA：
Guiping Zhao,Hengcun Li,Qingdong Guo,Anni Zhou,Xingyu Wang...&Shutian Zhang.(2020).Exosomal Sonic Hedgehog derived from cancer-associated fibroblasts promotes proliferation and migration of esophageal squamous cell carcinoma.CANCER MEDICINE,9,(7)
MLA：
Guiping Zhao,et al."Exosomal Sonic Hedgehog derived from cancer-associated fibroblasts promotes proliferation and migration of esophageal squamous cell carcinoma".CANCER MEDICINE 9..7(2020):2500-2513
