单位：[1]The First Affiliated Hospital Zhengzhou University, Biological Psychiatry International Joint Laboratory of Henan/Zhengzhou University, Henan Psychiatric Transformation Research Key Laboratory/Zhengzhou University, Zhengzhou, 450052, China[2]Department of Cardiology, Peking University people's Hospital, Beijing, 100201, China[3]Department of Cardiology, China-Japan Friendship Hospital, Beijing, 100029, China[4]Health Management Institute, Center for Statistical Analysis of Medical Data, Medical Big Data Analysis Center, Chinese PLA General Hospital, Beijing, 100191, China[5]School of Mental Health, Jining Medical University, Jining, 272119, Shandong Province, China[6]Psychiatric-Neuroimaging-Genetics-Comorbidity Laboratory, Tianjin Mental Health Centre, Mental Health Teaching Hospital of Tianjin Medical University, Tianjin Anding Hospital, School of Basic Medical Research, Tianjin Medical University, Tianjin, 300075, China[7]Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, China, MDT Center for Cognitive Impairment and Sleep Disorders, First Hospital of Shanxi Medical University, Taiyuan, 030001, China
Background: Depression is correlated with poor prognosis in patients with coronary artery disease (CAD). The goal of this meta-analysis was to assess the influence of depression on the risks of major adverse cardiovascular events (MACEs) and all-cause mortality after percutaneous coronary intervention (PCI). Methods: Cohort studies were obtained by searching PubMed and Embase databases. Cohort studies regarding the association between depression and risks of MACEs and mortality after PCI were included. Heterogeneity was determined using the Cochrane's Q test and calculated using I-2 . A fixed-effect model was used if no significant heterogeneity was detected; otherwise a random-effect model was applied. The adjusted risk ratio [RR] for the incidences of MACEs and all-cause mortality in patients with depression were compared to those without depression. Results: Nine cohorts including 4,555 CAD patients who underwent PCI were included in this meta-analysis, and 1,108 of these patients were diagnosed with depression. There were no significant differences among studies evaluating MACEs and mortality risks (I-2= 25% and 0%, respectively). Pooled results showed that depression was associated with higher risk of MACEs (RR: 2.10, 95% confidence interval [CI]: 1.59 to 2.77, p < 0.001) and all-cause mortality (RR: 1.76, 95% CI: 1.45 to 2.13, p < 0.001) during follow-up after PCI. Limitations: Available full text peer reviewed studies were limited and only studies in English were included in this analysis. Conclusions: Depressive symptoms were independently associated with adverse cardiovascular outcomes in patients who received PCI. Psychological therapy that does not increase cardiac burden or induce pharmacological side effects may be a better strategy to treat depression associated with PCI.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81871052, 81801679, 81571319]; Key Projects of the Natural Science Foundation of Tianjin, China [17JCZDJC35700]; Tianjin Health Bureau Foundation [2014KR02]; National Key Research and Development Program of China [2016YFC1307004]; Shanxi Science and Technology Innovation Training Team's Multidisciplinary Team for Cognitive Impairment [201705D131027]; Zhejiang Public Welfare Fund Project [LGF18H090002]; Wenzhou Science and Technology Bureau [ZS2017011]; Tianjin 131 Scholar Project; Tianjin Anding Hospital of 300000 Scholar Award Project
第一作者单位：[1]The First Affiliated Hospital Zhengzhou University, Biological Psychiatry International Joint Laboratory of Henan/Zhengzhou University, Henan Psychiatric Transformation Research Key Laboratory/Zhengzhou University, Zhengzhou, 450052, China
通讯作者：
通讯机构：[1]The First Affiliated Hospital Zhengzhou University, Biological Psychiatry International Joint Laboratory of Henan/Zhengzhou University, Henan Psychiatric Transformation Research Key Laboratory/Zhengzhou University, Zhengzhou, 450052, China[5]School of Mental Health, Jining Medical University, Jining, 272119, Shandong Province, China[6]Psychiatric-Neuroimaging-Genetics-Comorbidity Laboratory, Tianjin Mental Health Centre, Mental Health Teaching Hospital of Tianjin Medical University, Tianjin Anding Hospital, School of Basic Medical Research, Tianjin Medical University, Tianjin, 300075, China[7]Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, China, MDT Center for Cognitive Impairment and Sleep Disorders, First Hospital of Shanxi Medical University, Taiyuan, 030001, China[*1]Department of Psychiatry, The First Affiliated Hospital/Zhengzhou University, Zhengzhou, China[*2]Biological Psychiatry International Joint Laboratory of Henan/Zhengzhou University, Zhengzhou, China[*3]Henan Psychiatric Transformation Research Key Laboratory/Zhengzhou University, Zhengzhou, 450052, China
推荐引用方式(GB/T 7714)：
Song Xueqin,Song Junxian,Shao Mingjing,et al.Depression predicts the risk of adverse events after percutaneous coronary intervention: A meta-analysis[J].JOURNAL of AFFECTIVE DISORDERS.2020,266:158-164.doi:10.1016/j.jad.2020.01.136.
APA：
Song, Xueqin,Song, Junxian,Shao, Mingjing,Gao, Xiangyang,Ji, Feng...&Zhuo, Chuanjun.(2020).Depression predicts the risk of adverse events after percutaneous coronary intervention: A meta-analysis.JOURNAL of AFFECTIVE DISORDERS,266,
MLA：
Song, Xueqin,et al."Depression predicts the risk of adverse events after percutaneous coronary intervention: A meta-analysis".JOURNAL of AFFECTIVE DISORDERS 266.(2020):158-164
医学