单位：[1]China-Japan Friendship Hospital, Beijing, China[2]Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China[3]Beijing Haidian Center for Disease Control and Prevention, Beijing, China
Objectives: Explore the diagnostic and prognostic value of cyclooxygenase-2 and wnt3a/beta-catenin pathway in endometrial cancer. Methods: A prospective cohort study of 93 women underwent hysterectomy at the China-Japan Friendship Hospital (61 patients with primary endometrial carcinoma, and 32 control patients with uterine prolapse or leiomyoma of uterus). Cox2 and beta-catenin expression were determined by immunohistochemistry. The serum levels of cox2 and wnt3a were detected via ELISA assays. Results: Patients with endometrial cancer showed overexpression of cox2 and beta-catenin, as well as significantly higher serum levels of cox2 and wnt3a. The serum cox2 level, which is highly significant in predicting the risk of disease progression (RR, 9.617, 95% confidence interval, 1.162-79.622, P = 0.036), showed good diagnostic and prognostic potential, with cut-off of 55 U/L, but alongside beta-catenin expression in tissues, were related to poor prognosis (RR, 12.426; 95% confidence interval, 1.618-95.450; P = 0.015). Conclusion: Serum levels of cox2 and wnt3a exhibited diagnostic value for endometrial cancer. Cox2 serum levels and beta-catenin expression also showed potential value of prognostic prediction. Cox2 serum levels might be a potential marker for early diagnosis and prognosis prediction in endometrial cancer.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81372777]; Fundamental Research Funds for the Central Universities and Research Projects on Biomedical Transformation of China-Japan Friendship Hospital [PYBZ1820]
第一作者单位：[1]China-Japan Friendship Hospital, Beijing, China[2]Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
通讯作者：
通讯机构：[1]China-Japan Friendship Hospital, Beijing, China[2]Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
推荐引用方式(GB/T 7714)：
Deng Lin,Liang Haiyan,Han Yi.Cyclooxygenase-2 and beta-Catenin as Potential Diagnostic and Prognostic Markers in Endometrial Cancer[J].FRONTIERS in ONCOLOGY.2020,10:doi:10.3389/fonc.2020.00056.
APA：
Deng, Lin,Liang, Haiyan&Han, Yi.(2020).Cyclooxygenase-2 and beta-Catenin as Potential Diagnostic and Prognostic Markers in Endometrial Cancer.FRONTIERS in ONCOLOGY,10,
MLA：
Deng, Lin,et al."Cyclooxygenase-2 and beta-Catenin as Potential Diagnostic and Prognostic Markers in Endometrial Cancer".FRONTIERS in ONCOLOGY 10.(2020)
