单位：[1]National Integrated Traditional and Western Medicine Center for Cardiovascular Disease, China-Japan Friendship Hospital, Beijing, China[2]Department of psychiatry, School of Mental Health, Jining University, Jining, 27211, Shandong Province, China[3]Department of Psychiatry, Wenzhou Seventh People's Hospital, Wenzhou 325000, China[4]Psychiatric-Neuroimging-Genetics and Comorbidity Laboratory (PNGC-Lab), Tianjin Mental Health Center, Tianjin Anding Hospital, Tianjin 300222, China[5]Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, China[6]MDT Center for Cognitive Impairment and Sleep Disorders, First Hospital of Shanxi Medical University, Taiyuan 030001, China[7]Co-collaboration Laboratory of China and Canada, Xiamen Xianyue Hospital and University of Alberta, Xiamen Xianyue Hospital, Xiamen 361000, China[8]Center for Health Statistics, Big data center of chronic disease, Health Management Institute, 301 Hospital of Chinese People's Liberation Army, General Hospital of Chinese People's Liberation Army, 100191 Beijing, China
Importance: It has been suggested that patients with schizophrenia have higher than expected mortality following acute coronary events. However, the in-hospital revascularization rate in patients with schizophrenia and acute myocardial infarction (AMI) compared to mentally healthy patients remains unknown. Objective: To evaluate the revascularization rate in schizophrenic patients after AMI with a meta-analysis of observational studies. Data sources: PubMed and Embase electronical databases. Study selection: Observational studies that evaluate the likelihood of revascularization in AMI patients with schizophrenia compared to those without schizophrenia, after adjustment for potential influencing factors. Data extraction and synthesis: Data regarding study design, characteristics of the AMI patients and schizophrenic patients, and strategies of revascularization were extracted. Results were pooled and analyzed with a random effect model to incorporate the potential heterogeneity. Main outcome and measures: The likelihood of revascularization in AMI patients with schizophrenia compared to those without schizophrenia, after adjustment for potential influencing factors. Results: Overall, 3,260,754 hospitalized AMI patients from six follow-up studies were included, of which 17,875 patients had a prior diagnosis of schizophrenia. Results of this meta-analysis suggest that revascularization was significantly lower in AMI patients with schizophrenia compared to those without schizophrenia (odds ratio [OR]: 0.48, 95% confidence interval [CI]: 0.38 to 0.62, p < .001; I-2 = 93%), after adjustment for demographic characteristics, comorbidities, and hospital and regional factors. Specifically, AMI patients with schizophrenia had significantly fewer percutaneous coronary interventions (OR: 0.48, 95% CI: 0.41 to 0.56, p < .001; I-2 = 49%) and coronary artery bypass grafts (OR: 0.61, 95% CI: 0.53 to 0.70, p < .001; I-2 = 20%) compared to those without schizophrenia. Conclusions and relevance: Patients with schizophrenia and AMI have a lower rate of coronary revascularization as compared with patients without schizophrenia, which is an important cause of higher-than-expected mortality rate in this population.
第一作者单位：[1]National Integrated Traditional and Western Medicine Center for Cardiovascular Disease, China-Japan Friendship Hospital, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[2]Department of psychiatry, School of Mental Health, Jining University, Jining, 27211, Shandong Province, China[3]Department of Psychiatry, Wenzhou Seventh People's Hospital, Wenzhou 325000, China[4]Psychiatric-Neuroimging-Genetics and Comorbidity Laboratory (PNGC-Lab), Tianjin Mental Health Center, Tianjin Anding Hospital, Tianjin 300222, China[5]Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, China[6]MDT Center for Cognitive Impairment and Sleep Disorders, First Hospital of Shanxi Medical University, Taiyuan 030001, China[7]Co-collaboration Laboratory of China and Canada, Xiamen Xianyue Hospital and University of Alberta, Xiamen Xianyue Hospital, Xiamen 361000, China[*1]Department of psychiatry, Tianjin Medical University, No. 22 Qixiangtai Rd, Heping District, Tianjin 300072, China
推荐引用方式(GB/T 7714)：
Shao Mingjing,Zhuo Chuanjun,Gao Xiangyang,et al.Reduced rate of revascularization in schizophrenic patients with acute myocardial infarction: A systematic review and meta-analysis[J].PROGRESS in NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY.2020,99:doi:10.1016/j.pnpbp.2020.109870.
APA：
Shao, Mingjing,Zhuo, Chuanjun,Gao, Xiangyang,Chen, Ce,Xu, Yong...&Wang, Wenqiang.(2020).Reduced rate of revascularization in schizophrenic patients with acute myocardial infarction: A systematic review and meta-analysis.PROGRESS in NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,99,
MLA：
Shao, Mingjing,et al."Reduced rate of revascularization in schizophrenic patients with acute myocardial infarction: A systematic review and meta-analysis".PROGRESS in NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 99.(2020)
