单位：[1]Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China临床科室耳鼻咽喉头颈外科耳鼻咽喉头颈外科首都医科大学附属北京友谊医院
Objective: Nicotinamide riboside (NR) has been proved to protect the hearing. To achieve animal models of temporary threshold shift (TTS) and permanent threshold shift (PTS) respectively, evaluate the dynamic change of ribbon synapse before and after NR administration. Methods: Mice were divided into control group, noise exposure (NE) group and NR group. The noise was exposed to NE and NR group, and NR was injected before noise exposure. Auditory brainstem response (ABR), ribbon synapse count and cochlear morphology were tested, as well as the concentration of hydrogen peroxide (H2O2) and ATP. Results: Ribbon synapse count decrease with the intensity of noise exposure, and the cochlear morphology remains stable during TTS and was damaged during PTS. NR promotes the oxidation resistance to protect the synapse and the inner ear morphology. Conclusion: Our findings suggest that TTS mice are more vulnerable to noise, and NR can promote the recovery of the synapse count to protect the animals' hearing.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81830030]
第一作者单位：[1]Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
通讯作者：
通讯机构：[1]Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China[*1]Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, 95th Yong’an Road, Xicheng District, Beijing 100050, China.
推荐引用方式(GB/T 7714)：
Han Shuguang,Du Zhengde,Liu Ke,et al.Nicotinamide riboside protects noise-induced hearing loss by recovering the hair cell ribbon synapses[J].NEUROSCIENCE LETTERS.2020,725:doi:10.1016/j.neulet.2020.134910.
APA：
Han, Shuguang,Du, Zhengde,Liu, Ke&Gong, Shusheng.(2020).Nicotinamide riboside protects noise-induced hearing loss by recovering the hair cell ribbon synapses.NEUROSCIENCE LETTERS,725,
MLA：
Han, Shuguang,et al."Nicotinamide riboside protects noise-induced hearing loss by recovering the hair cell ribbon synapses".NEUROSCIENCE LETTERS 725.(2020)
