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miRNA-150-5p promotes hepatic stellate cell proliferation and sensitizes hepatocyte apoptosis during liver fibrosis

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收录情况： ◇ SCIE

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单位： [1]Experimental & Translational Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, PR China [2]Beijing Key Laboratory of Tolerance Induction & Organ Protection in Transplantation, Beijing Friendship Hospital, Capital Medical University, Beijing, PR China [3]Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis, National Clinical Research Center of Digestive Diseases, Beijing, PR China

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关键词： apoptosis cell specific hepatic stellate cell hepatocyte liver fibrosis miR-150-5p proliferation transcriptome

摘要：

Aim: To explore the role of miRNA-150-5p (miR-150-5p) in liver fibrosis. Materials & methods: miRNA expression profiles, CCl4-induced liver fibrosis progression and regression rodent models, quantitative realtime PCR, miR-150-5p mimics and inhibitors, cell proliferation and apoptosis detection, RNA sequencing and bioinformatics analysis were employed. Results: Liver tissuemiR-150-5p expression was positively associated with liver fibrosis progression and regression; however, miR-150-5p exhibited a cell-specific expression pattern, namely, it was enhanced in hepatocytes but reduced in hepatic stellate cells (HSCs) during liver fibrosis; miR-150-5p overexpression promoted HSC apoptosis and sensitized hepatocyte apoptosis; miR-150-5p mimic had a larger influence on the transcriptomic stability of HSCs than that of hepatocytes; miR-150-5p mediated activation of interferon signaling pathways might be responsible for HSC apoptosis. Conclusion: miR-150-5p exhibited an opposite regulation and function pattern between HSCs and hepatocytes during liver fibrosis.

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出版当年[2019]版：

大类 | 2 区医学

小类 | 2 区遗传学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区遗传学

JCR分区：

出版当年[2018]版：

Q1 GENETICS & HEREDITY

最新[2023]版：

Q2 GENETICS & HEREDITY

影响因子： 最新[2023版] 3 最新五年平均[2021-2025] 3.4 出版当年[2018版] 4.404 出版当年五年平均[2014-2018] 4.855 出版前一年[2017版] 4.979 出版后一年[2019版] 4.112

第一作者：

第一作者单位： [1]Experimental & Translational Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, PR China [2]Beijing Key Laboratory of Tolerance Induction & Organ Protection in Transplantation, Beijing Friendship Hospital, Capital Medical University, Beijing, PR China

通讯作者：

通讯机构： [1]Experimental & Translational Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, PR China [2]Beijing Key Laboratory of Tolerance Induction & Organ Protection in Transplantation, Beijing Friendship Hospital, Capital Medical University, Beijing, PR China [3]Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis, National Clinical Research Center of Digestive Diseases, Beijing, PR China

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