单位：[1]Department of Pulmonary and Critical Care Medicine, Laboratory of Clinical Microbiology and Infectious Diseases, Center for Respiratory Diseases, National Clinical Research Center of Respiratory Diseases, China-Japan Friendship Hospital, Beijing, China[2]Clinical Center for Pulmonary Infections, Capital Medical University, Beijing, China[3]Tsinghua University-Peking University Joint Center for Life Sciences, Beijing, China
Background Respiratory syncytial virus (RSV) is an important cause of medically attended acute respiratory illnesses in older adults but awareness of the relevance of RSV in older people remains lower than that of influenza, which exhibits similar clinical characteristics to those of RSV. Objectives This study was performed to assess the clinical significance of RSV in respiratory samples from hospitalized adults. Methods Characteristics and outcomes in adults (>= 18 years) hospitalized for RSV infection (n = 51) were compared with a cohort hospitalized for influenza A infection (n = 279) in a single-center retrospective cohort study in Beijing, China. Results Respiratory syncytial virus patients were slightly older, with no significant differences in underlying chronic conditions. Lower respiratory tract infection and cardiovascular complications were more frequent (P < .05) in RSV patients. Rates of mortality in the RSV cohorts were significantly higher within 30 days (13.7% vs 5.0%, P = .019) and 60 days (17.6% vs 7.5%, P = .021). Bacterial co-infection in respiratory samples was associated with reduced survival among RSV patients (log rank, P = .013). Conclusions Respiratory syncytial virus is a common cause of serious illness among hospitalized adults in China with greater mortality than influenza A. Increased awareness and the availability of antiviral agents might increase the scope for successful management.
基金：
National Science Fund for Distinguished Young ScholarsNational Natural Science Foundation of China (NSFC)National Science Fund for Distinguished Young Scholars [81425001/H0104]; CAMS Innovation Fund for Medical Sciences [CIFMS 2018-I2M-1-003]; Intramural Research Program of China-Japan Friendship Hospital [2018-2-QN-22]
第一作者单位：[1]Department of Pulmonary and Critical Care Medicine, Laboratory of Clinical Microbiology and Infectious Diseases, Center for Respiratory Diseases, National Clinical Research Center of Respiratory Diseases, China-Japan Friendship Hospital, Beijing, China
通讯作者：
通讯机构：[1]Department of Pulmonary and Critical Care Medicine, Laboratory of Clinical Microbiology and Infectious Diseases, Center for Respiratory Diseases, National Clinical Research Center of Respiratory Diseases, China-Japan Friendship Hospital, Beijing, China[2]Clinical Center for Pulmonary Infections, Capital Medical University, Beijing, China[3]Tsinghua University-Peking University Joint Center for Life Sciences, Beijing, China[*1]Department of Pulmonary and Critical Care Medicine, Center for Respiratory Diseases, National Clinical Research Center of Respiratory Diseases, China-Japan Friendship Hospital, Beijing, China.
推荐引用方式(GB/T 7714)：
Zhang Yulin,Wang Yeming,Zhao Jiankang,et al.Severity and mortality of respiratory syncytial virus vs influenza A infection in hospitalized adults in China[J].INFLUENZA and OTHER RESPIRATORY VIRUSES.2020,14(5):483-490.doi:10.1111/irv.12754.
APA：
Zhang, Yulin,Wang, Yeming,Zhao, Jiankang,Xiong, Zhujia,Fan, Yanyan...&Cao, Bin.(2020).Severity and mortality of respiratory syncytial virus vs influenza A infection in hospitalized adults in China.INFLUENZA and OTHER RESPIRATORY VIRUSES,14,(5)
MLA：
Zhang, Yulin,et al."Severity and mortality of respiratory syncytial virus vs influenza A infection in hospitalized adults in China".INFLUENZA and OTHER RESPIRATORY VIRUSES 14..5(2020):483-490
