单位：[1]State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China[2]School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China[3]Department of Gastroenterology, China-Japan Friendship Hospital, Beijing 100029, China
Dipeptide self-assembled hydrogels have potential biomedical applications because of their great biocompatibility, bioactivity, and tunable physicochemical properties, which can be modulated in the molecular level by design of amino acid sequences. Herein, a series of dipeptides (Fmoc-FL, -YL, -LL, and -YA) are designed to form shear-thinning hydrogels with self-healing and tunable mechanical properties by adjusting the synergetic effect of hydrophobic interactions (p-p stacking and hydrophobic effect) and hydrogen bonds of peptides through substitution of amino acid residues. The enhancement of hydrophobic interactions is a primary factor to promote mechanical rigidity of hydrogels, and strong hydrogen-bonding interactions between molecules contribute to the instantaneous self-healing property, which is supported by experimental studies (FTIR, CD, SEM, AFM, and rheology) and molecular dynamics simulations. The injectable dipeptide hydrogels were certified as an ideal endoscopic submucosal dissection filler to make operation convenient and secure in mice and living mini-pig's experiments with a longer duration time, higher stiffness, and lower inflammatory response than commercial clinical fillers.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21774132, 21703253]; China-Japan Friendship Hospital Research funding [2016-1-MS-5]; Open Funding Project of the State Key Laboratory of Biochemical Engineering [2019KF-02]
第一作者单位：[1]State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China[2]School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China
共同第一作者：
通讯作者：
通讯机构：[1]State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China[2]School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China[3]Department of Gastroenterology, China-Japan Friendship Hospital, Beijing 100029, China[*1]Department of Gastroenterology, China-Japan Friendship Hospital, Beijing 100029, China[*2]State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China[*3]School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China
推荐引用方式(GB/T 7714)：
Ren Peng,Li Jingtao,Zhao Luyang,et al.Dipeptide Self-assembled Hydrogels with Shear-Thinning and Instantaneous Self-healing Properties Determined by Peptide Sequences[J].ACS APPLIED MATERIALS & INTERFACES.2020,12(19):21433-21440.doi:10.1021/acsami.0c03038.
APA：
Ren, Peng,Li, Jingtao,Zhao, Luyang,Wang, Anhe,Wang, Meiyue...&Bai, Shuo.(2020).Dipeptide Self-assembled Hydrogels with Shear-Thinning and Instantaneous Self-healing Properties Determined by Peptide Sequences.ACS APPLIED MATERIALS & INTERFACES,12,(19)
MLA：
Ren, Peng,et al."Dipeptide Self-assembled Hydrogels with Shear-Thinning and Instantaneous Self-healing Properties Determined by Peptide Sequences".ACS APPLIED MATERIALS & INTERFACES 12..19(2020):21433-21440
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