单位：[1]Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, China [2]Department of Orthopedic Surgery, China-Japan Friendship Hospital, Beijing 100029, China [3]Multiple Myeloma Research Center of Beijing, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China北京朝阳医院
Objectives. To investigate the incidence and risk factors for osteonecrosis of femoral head (ONFH) in multiple myeloma (MM) patients undergoing dexamethasone-based regimens (DBRs). Methods. A retrospective study was conducted in MM patients administered DBRs between December 2012 and April 2015. Demographic, clinical, and laboratory data were extracted to compare between two groups. Incidence of ONFH were calculated and risk factors identified by both univariate and multivariate analysis. Results. The study group comprised 105 patients undergoing DBRs. Seven patients with ONFH after DBRs were classified as the ONFH group, and the other 98 patients without ONFH were included in the non-ONFH group. Incidence of ONFH was 6.7%. Median age of developing ONFH was 51 years (45-64), and the male to female ratio was 6 : 1. A total of 12 femoral heads were involved, including unilateral in 2 patients and bilateral in 5 patients. After the multivariate analysis, four risk factors were confirmed including male, younger age, cumulative dose of dexamethasone, and hyperlipidemia. Conclusion. The overall incidence of ONFH in MM patients treated with DBRs is 6.7%, and 4 risk factors are confirmed including male, younger age, cumulative dose of dexamethasone, and hyperlipidemia in our study.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81672236, 81871830]; Natural Science Foundation of Beijing MunicipalityBeijing Natural Science Foundation [7182146]; Fundamental Research Funds for the Central Universities and Research Projects on Biomedical Transformation of China?Japan Friendship Hospital [PYBZ1828]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|3 区生物
小类|3 区生物工程与应用微生物4 区医学：研究与实验
最新[2025]版：
大类|4 区医学
小类|4 区生物工程与应用微生物4 区医学：研究与实验
JCR分区：
出版当年[2018]版：
Q3MEDICINE, RESEARCH & EXPERIMENTALQ3BIOTECHNOLOGY & APPLIED MICROBIOLOGY
最新[2024]版：
Q3BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ3MEDICINE, RESEARCH & EXPERIMENTAL
第一作者单位：[1]Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, China [2]Department of Orthopedic Surgery, China-Japan Friendship Hospital, Beijing 100029, China
通讯作者：
通讯机构：[1]Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, China [2]Department of Orthopedic Surgery, China-Japan Friendship Hospital, Beijing 100029, China
推荐引用方式(GB/T 7714)：
Wu Xinjie,Geng Chuanying,Sun Wei,et al.Incidence and Risk Factors of Osteonecrosis of Femoral Head in Multiple Myeloma Patients Undergoing Dexamethasone-Based Regimens[J].BIOMED RESEARCH INTERNATIONAL.2020,2020:doi:10.1155/2020/7126982.
APA：
Wu, Xinjie,Geng, Chuanying,Sun, Wei&Tan, Mingsheng.(2020).Incidence and Risk Factors of Osteonecrosis of Femoral Head in Multiple Myeloma Patients Undergoing Dexamethasone-Based Regimens.BIOMED RESEARCH INTERNATIONAL,2020,
MLA：
Wu, Xinjie,et al."Incidence and Risk Factors of Osteonecrosis of Femoral Head in Multiple Myeloma Patients Undergoing Dexamethasone-Based Regimens".BIOMED RESEARCH INTERNATIONAL 2020.(2020)
