单位：[1]Department of Laboratory Medicine, China-Japan Friendship Hospital,Beijing 100029, China[2]Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing 100029, China[3]Graduate School of Peking Union MedicalCollege, Chinese Academy of Medical Sciences/Peking Union MedicalCollege, Beijing 100193, China
Background Previous studies reported that the association between lipid levels and cognitive function is related with gender, age and specific cognitive domains, but the influence of body mass index (BMI) on this association is limited. This triggered interest in exploring how serum lipids relate to cognitive function in different subgroups. Methods Data was collected from 2009 wave and 2015 wave of China Health and Nutrition Survey (CHNS). Multivariable linear regression analyses examined serum lipids level as predictors of sex- and age-specific measure of cognitive function in different BMI levels, which were adjusted for nationality, BMI, systolic blood pressure (SBP), diastolic blood pressure (DBP), smoking status, alcohol consumption and education level. Results Cognitive function score have different concentration curves in serum lipids quartile levels in different BMI categories. After adjustment for confounding factors, serum TG was positively associated with cognitive function score in underweight (beta +/- SE: 2.06 +/- 0.88, P = 0.023) and obese (beta +/- SE: 1.44 +/- 0.71, P = 0.045) male group, and serum HDL-C was positively associated with cognitive function score in overweight (beta +/- SE: 1.89 +/- 0.92, P = 0.041) and obese (beta +/- SE: 5.04 +/- 1.62, P = 0.002) female group. Serum TC was negatively associated with cognitive function score in overweight (beta +/- SE: - 2.55 +/- 1.26, P = 0.043) mid-life adults, and serum HDL-C was positively associated with cognitive function score in overweight (beta +/- SE: 2.15 +/- 0.94, P = 0.022) and obese (beta +/- SE: 5.33 +/- 2.07, P = 0.011) older adults. Conclusion The associations of serum lipids with cognitive function were related with BMI levels and differed between gender and age groups. This result indicated that better nutritional status has superior cognitive function performance.
基金：
National Institute for Nutrition and Health; China Center for Disease Control and Prevention; Carolina Population Center [P2C HD050924, T32 HD007168]; University of North Carolina at Chapel Hill; NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01-HD30880, DK056350, R24 HD050924, R01-HD38700]; NIH Fogarty International CenterUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH Fogarty International Center (FIC) [D43 TW009077, D43 TW007709]; China-Japan Friendship Hospital, Ministry of Health; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81202766]
第一作者单位：[1]Department of Laboratory Medicine, China-Japan Friendship Hospital,Beijing 100029, China
通讯作者：
通讯机构：[2]Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing 100029, China[3]Graduate School of Peking Union MedicalCollege, Chinese Academy of Medical Sciences/Peking Union MedicalCollege, Beijing 100193, China
推荐引用方式(GB/T 7714)：
Li Jiang,Cao Yongtong,Xiao Cheng.Subgroup analysis of the influence of body mass index on the association between serum lipids and cognitive function in Chinese population[J].LIPIDS in HEALTH and DISEASE.2020,19(1):doi:10.1186/s12944-020-01314-7.
APA：
Li, Jiang,Cao, Yongtong&Xiao, Cheng.(2020).Subgroup analysis of the influence of body mass index on the association between serum lipids and cognitive function in Chinese population.LIPIDS in HEALTH and DISEASE,19,(1)
MLA：
Li, Jiang,et al."Subgroup analysis of the influence of body mass index on the association between serum lipids and cognitive function in Chinese population".LIPIDS in HEALTH and DISEASE 19..1(2020)
