单位：[1]Department of Emergency, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.北京朝阳医院[2]Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing, China.[3]Department of Emergency, Beijing Fu-Xing Hospital, Capital Medical University, Beijing, China.[4]Department of Emergency, Beijing Tongren Hospital, Capital Medical University, Beijing, China.首都医科大学附属同仁医院[5]Department of Emergency, Beijing Friendship Hospital, Capital Medical University, Beijing, China.临床科室急危重症及感染医学中心急诊医学科首都医科大学附属北京友谊医院
To investigate the different effects of mild hypothermia on pathological and physiological stress conditions in piglets, 30 pigs were randomized into four groups: cardiac arrest and mild hypothermia (CA-MH group), cardiac arrest and normothermia (CA-NH group), non-CA-MH (NCA-MH group), and a sham operation. The same hypothermia intervention was implemented in both CA-MH and NCA-MH groups. The CA-NH group did not undergo therapeutic hypothermia after resuscitation. The hemodynamic parameters were recorded. Cerebral metabolism variables and neurotransmitters in the extracellular fluid were collected through microdialysis tubes. The serum of venous blood was used to detect levels of inflammatory factors. The cerebral function was evaluated. At 24 and 72 hours after resuscitation, the cerebral performance category and neurological deficit score in the CA-NH group had higher values. Heart rate and cardiac output (CO) in the CA-MH group during cooling were lower than that of the CA-NH group, but CO was higher after rewarming. Glucose was higher during cooling, and extracellular lactate and lactate/pyruvate ratio in the CA-MH group were lower than that of the CA-NH group. Noradrenaline and 5-hydroxytryptamine in the CA-MH and NCA-MH groups were lower than that of the CA-NH group and sham group during cooling, respectively. Inflammatory factor levels, including interleukin (IL)-1, IL-2, IL-4, IL-6, IL-8, and tumor necrosis factor-, in the CA-MH group were lower than that of the CA-NH group at cooling for 12 hours. These values in the NCA-MH group were higher than that of the sham group. Under a light and an electron microscope, the worse pathological results of heart and brain were observed in the two cardiac arrest groups. Mild hypothermia can provide limited organ protection in the specific pathological condition caused by ischemia-reperfusion, but it may produce a negative effect in a normal physiological state.
基金：
Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation Foundation
第一作者单位：[1]Department of Emergency, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.[2]Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing, China.
通讯作者：
通讯机构：[1]Department of Emergency, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.[2]Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing, China.[*1]Department of Emergency Beijing Chao-Yang Hospital Capital Medical University Beijing 100020 China
推荐引用方式(GB/T 7714)：
Yuan Wei,Wu Jun-Yuan,Zhao Yong-Zhen,et al.Effects of Mild Hypothermia on Cardiac and Neurological Function in Piglets Under Pathological and Physiological Stress Conditions[J].THERAPEUTIC HYPOTHERMIA and TEMPERATURE MANAGEMENT.2019,9(2):136-145.doi:10.1089/ther.2018.0026.
APA：
Yuan, Wei,Wu, Jun-Yuan,Zhao, Yong-Zhen,Li, Jie,Li, Jie-Bin...&Li, Chun-Sheng.(2019).Effects of Mild Hypothermia on Cardiac and Neurological Function in Piglets Under Pathological and Physiological Stress Conditions.THERAPEUTIC HYPOTHERMIA and TEMPERATURE MANAGEMENT,9,(2)
MLA：
Yuan, Wei,et al."Effects of Mild Hypothermia on Cardiac and Neurological Function in Piglets Under Pathological and Physiological Stress Conditions".THERAPEUTIC HYPOTHERMIA and TEMPERATURE MANAGEMENT 9..2(2019):136-145
