单位：[1]Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, China临床科室泌尿外科泌尿外科首都医科大学附属北京友谊医院[2]Department of Clinical Laboratory, Peking University People’s Hospital, Beijing, China
Renal ischemia/reperfusion (IR) injury is one of the most important risk factors for the occurrence of delayed graft function (DGF) after kidney transplantation; however, its mechanism remains not fully understood. In the present study, we screened differentially expressed genes in a murine model of renal IR injury by using high-throughput assays. We identified Corin as one of the most significantly downregulated genes among 2218 differentially expressed genes (2-fold, P<0.05). By using a real-time qPCR assay, we observed that the expression of renal Corin in IR-injured mice was reduced to 11.5% of the sham-operated mice and that the protein level of renal Corin in IR-injured mice was also downregulated. Interestingly, renal IR injury in mice induced the downregulation of Corin in heart tissues, suggesting that the overall synthesis of Corin may be suppressed. We recruited 11 recipients complicated with DGF and 16 without DGF, and plasma Corin concentrations were determined by ELISA. We observed that the plasma Corin levels were indeed reduced in recipients complicated with DGF (0.98 vs. 1.95ng/ml, P<0.05). These findings demonstrate that Corin may be a potential biomarker of DGF after kidney transplantation and may participate in the regulation of renal IR injury.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81602214]; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support [ZYLX201604]
语种：
外文
被引次数：
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PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|3 区医学
小类|3 区生物工程与应用微生物3 区病理学4 区遗传学4 区医学：研究与实验
最新[2025]版：
无
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出版当年[2017]版：
Q2BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ2GENETICS & HEREDITYQ2MEDICINE, RESEARCH & EXPERIMENTALQ2PATHOLOGY
第一作者单位：[1]Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, China
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推荐引用方式(GB/T 7714)：
Xinyi Hu,Ming Su,Jun Lin,et al.Corin Is Downregulated in Renal Ischemia/Reperfusion Injury and Is Associated with Delayed Graft Function after Kidney Transplantation[J].DISEASE MARKERS.2019,2019:doi:10.1155/2019/9429323.
APA：
Xinyi Hu,Ming Su,Jun Lin,Lei Zhang,Wen Sun...&Wei Qiu.(2019).Corin Is Downregulated in Renal Ischemia/Reperfusion Injury and Is Associated with Delayed Graft Function after Kidney Transplantation.DISEASE MARKERS,2019,
MLA：
Xinyi Hu,et al."Corin Is Downregulated in Renal Ischemia/Reperfusion Injury and Is Associated with Delayed Graft Function after Kidney Transplantation".DISEASE MARKERS 2019.(2019)
