Objective: To improve the prognosis and patient survival rate through clinicopathological features analysis of multiple primary neoplasms (MPMNs) with endometrial carcinoma. Method: In this study, 31 patients suffering from multiple primary neoplasms among 397 cases of endometrial carcinomas that were operated on in our hospital from 2003 to 2015 were examined. The tumor distribution, clinical and pathological features, and survival rate were studied, respectively. Results: The incidence of multiple primary neoplasms was 7.8% among those with endometrial carcinoma with the median age of 50.3 years old. The major organs involved were the colon, rectum, ovary, breast, and lung. The 5-year survival rate of endometrial carcinomas with MPMN is 22.6%, and the median survival time is 70 +/- 26.86 months. However, the cumulative survival rate at 5 years is 55.8% which is below the 5-year survival rate of any primary malignant neoplasm. The median interval time from the first primary cancer diagnosis to the second cancer diagnosis exceeding 3 years will prolong life time. Conclusion: The major primary malignant neoplasms associated with endometrial carcinoma include those of the colon, rectum, ovary, breast, and lung. The 5-year survival rate is lower than any primary neoplasms. The median interval time from the first primary cancer diagnosis to the second cancer diagnosis exceeding 3 years will prolong life time.