单位：[1]Department of Orthopaedics, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.临床科室骨科骨科首都医科大学附属北京友谊医院[2]Department of Pain, Tongliang Hospital of Traditional Chinese Medicine Affiliated to Chinese Medicine of Chongqing Medical University, Chongqin 402560, China.
lncRNA LOXL1 antisense RNA 1 (lncRNA LOXL1-AS1) was recently found to function as oncogenic lncRNA in glioblastoma, prostate cancer, and medulloblastoma. The role of LOXL1-AS1 in osteosarcoma was still unknown. In our study, we found LOXL1-AS1 expression levels were higher in osteosarcoma tissues and cell lines than normal bone tissues and normal osteoblast cell line, respectively. Moreover, high-expression of LOXL1-AS1 was correlated with Enneking stage, tumor size, distant metastasis, histological grade, and overall survival time in osteosarcoma patients. Furthermore, LOXL1-AS1 overexpression acted as an independent poor predictor for overall survival in osteosarcoma patients. The loss-of-function studies showed knockdown of LOXL1-AS1 dramatically inhibited osteosarcoma cell proliferation, migration, and invasion through suppressing PI3K-AKT pathway. In conclusion, LOXL1-AS1 predicts clinical progression and poor prognosis in osteosarcoma patients and functions as oncogenic lncRNA to regulate cell proliferation, cell cycle, migration, and invasion.
第一作者单位：[1]Department of Orthopaedics, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Orthopaedics, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.[*1]Department of Orthopaedics, Beijing Friendship Hospital, Capital Medical University, No.95 Yongan Road, Beijing 100050, China.
推荐引用方式(GB/T 7714)：
Chen Si,Li Weiguo,Guo Ai.LOXL1-AS1 predicts poor prognosis and promotes cell proliferation, migration, and invasion in osteosarcoma[J].BIOSCIENCE REPORTS.2019,39:doi:10.1042/BSR20190447.
APA：
Chen, Si,Li, Weiguo&Guo, Ai.(2019).LOXL1-AS1 predicts poor prognosis and promotes cell proliferation, migration, and invasion in osteosarcoma.BIOSCIENCE REPORTS,39,
MLA：
Chen, Si,et al."LOXL1-AS1 predicts poor prognosis and promotes cell proliferation, migration, and invasion in osteosarcoma".BIOSCIENCE REPORTS 39.(2019)
