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Daturanolide A-C, Three New Withanolides from Datura metel L. and Their Cytotoxic Activities

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收录情况： ◇ SCIE

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单位： [1]School of Life Sciences & School of Chinese Medicine Sciences, Beijing University of Chinese Medicine, Beijing 100029, P. R. China [2]Institute of Clinical Medical Sciences & Department of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, P. R. China [3]College of Life Sciences/Nanjiang Key Laboratory of Chemical Resources Utilization Engineering in Tarim Basin of Xinjiang Production and Construction Corps, Tarim University, Alar 843300, P. R. China [4]College of Pharmaceutical and Biotechnology Engineering, Institute of Functional Molecules, Shenyang University of Chemical Technology, Shenyang 110142, P. R. China

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关键词： Datura metel L withanolides daturanolide A-C cytotoxicity structure elucidation

摘要：

Three new withanolides (1-3), named as daturanolide A-C, along with six known withanolides (4-9) were isolated from the flowers of Datura metel L. Their structures with absolute configurations were elucidated by a series of spectroscopic methods, electronic circular dichroism (ECD) analyses, and X-ray crystallography. All the isolates were evaluated for cytotoxicity against five human cancer cell lines (HCT116, U87-MG, NCI-H460, BGC823, and HepG2), and 6 exhibited marked cytotoxicity.

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出版当年[2018]版：

大类 | 4 区环境科学与生态学

小类 | 4 区生化与分子生物学 4 区化学综合

最新[2025]版：

大类 | 3 区化学

小类 | 3 区化学：综合 4 区生化与分子生物学

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出版当年[2017]版：

Q3 CHEMISTRY, MULTIDISCIPLINARY Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 CHEMISTRY, MULTIDISCIPLINARY

影响因子： 最新[2023版] 2.3 最新五年平均[2021-2025] 2.5 出版当年[2017版] 1.617 出版当年五年平均[2013-2017] 1.624 出版前一年[2016版] 1.44 出版后一年[2018版] 1.449

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第一作者单位： [1]School of Life Sciences & School of Chinese Medicine Sciences, Beijing University of Chinese Medicine, Beijing 100029, P. R. China [2]Institute of Clinical Medical Sciences & Department of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, P. R. China

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