单位：[1]Department of Otorhinolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China首都医科大学附属北京友谊医院
Previous studies examining the association of leptin receptor (LEPR) Gln223Arg polymorphism with obstructive sleep apnea-hypopnea syndrome (OSAHS) risk have yielded controversial outcomes. We aimed to clarify whether LEPR Gln223Arg polymorphism was critically involved in the development of OSAHS. We thoroughly searched PubMed as well as CNKI datasets for collection of relevant studies, followed by analysis of odds ratios (ORs) with corresponding 95% confidence intervals (CIs). Of the seven case-control studies we enrolled, there was insignificant correlation of the LEPR Gln223Arg polymorphism with OSAHS risk. However, subgroup analysis by Newcastle-Ottawa scale (NOS) scores revealed that, LEPR Gln223Arg polymorphism was significantly related to OSAHS risk in high-quality studies. In addition, we found no publication bias. Our findings suggest that LEPR Gln223Arg polymorphism might contribute to the risk of OSAHS. Well-designed studies with more subjects are needed for further validation of these results.
基金：
program of Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support [XMLX201703]
第一作者单位：[1]Department of Otorhinolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China[*1]Department of Otorhinolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, No. 95, Yongan Lu, Xicheng District, Beijing, 100050, China
通讯作者：
通讯机构：[1]Department of Otorhinolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China[*1]Department of Otorhinolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, No. 95, Yongan Lu, Xicheng District, Beijing, 100050, China
推荐引用方式(GB/T 7714)：
Zhu Mei,Bai Xue.Association of LEPR Gln223Arg Polymorphism with Obstructive Sleep Apnea Syndrome: A Meta-Analysis[J].CRITICAL REVIEWS in EUKARYOTIC GENE EXPRESSION.2019,29(2):170-175.doi:10.1615/CritRevEukaryotGeneExpr.2019025748.
APA：
Zhu, Mei&Bai, Xue.(2019).Association of LEPR Gln223Arg Polymorphism with Obstructive Sleep Apnea Syndrome: A Meta-Analysis.CRITICAL REVIEWS in EUKARYOTIC GENE EXPRESSION,29,(2)
MLA：
Zhu, Mei,et al."Association of LEPR Gln223Arg Polymorphism with Obstructive Sleep Apnea Syndrome: A Meta-Analysis".CRITICAL REVIEWS in EUKARYOTIC GENE EXPRESSION 29..2(2019):170-175
