Association between the concurrence of pre-existing chronic liver disease and worse prognosis in patients with an herb- Polygonum multiflorum thunb. induced liver injury: a case-control study from a specialised liver disease center in China
单位：[1]Department of Integrative Medicine, Medical School of Chinese PLA, Beijing, China[2]Division of Integrative Medicine, Beijing 302 Hospital, Beijing, China[3]Liver Research Center, Beijing Friendship Hospital, Capital Medial University, Beijing, China临床科室国家中心肝病分中心首都医科大学附属北京友谊医院[4]Institute of Chinese Herbal Medicine, Beijing 302 Hospital, Beijing, China
Objectives The present study aimed to evaluate the association between the concurrence of pre-existing chronic liver diseases (CLD) and worse prognosis in patients with HILI. Design A case-control study. Setting Tertiary hospital specialising in liver diseases in China. Participants 145 hospitalised HILI patients were assessed with respect to prognosis by comparing HILI with or without pre-existing CLD from February 2007 to January 2017. Twenty-five HILI cases with pre-existing alcoholic liver disease (ALD) or non-alcoholic fatty liver disease (NAFLD) and 200 ALD or NAFLD controls matched 1: 8 for sex, age (+/- 4 years old), body mass index (+/- 2 kg/ m2), the type of CLD, alcohol intake (+/- 5 g/d) and the presence or absence of cirrhosis. Primary outcome measures Mortality and chronicity in HILI patients with or without pre-existing CLD, and matched CLD patients. Results Of the 193 714 hospitalised patients with liver diseases, 5703 patients met the diagnostic criteria for drug-induced liver injury (DILI), which was attributed to Polygonum multiflorum Thunb. (PMT) in 145 patients. Among these HILI patients, 22.8% (33 of 145) had preexisting CLD, including 17 (51.5%) with ALD, 8 (24.2%) with NAFLD, 5 (15.2%) with chronic viral hepatitis and 3 (9.1%) with autoimmune liver disease. Compared with HILI patients without CLD, HILI patients with pre-existing CLD showed higher mortality (0.9% vs 9.1%, p= 0.037) and higher chronicity (12.5% vs 30.3%, p= 0.016). Compared with matched ALD (136 patients) or NAFLD (64 patients) patients, HILI patients with pre-existing ALD showed higher chronicity (35.3% vs 11.8%, p= 0.019). Multivariate logistic regression analysis found that concurrence of pre-existing CLD was an independent risk factor for both of chronicity and mortality (OR 3.966, 95% CI 1.501 to 10.477, p= 0.005), especially the chronicity (OR 3.035, 95% CI 1.115 to 8.259, p= 0.030). Conclusions Concurrence of pre-existing CLD could be an independent risk factor for worse prognosis, especially chronicity, in PMT-related HILI.
基金：
National Key Technology RD ProgramNational Key Technology R&D Program [2015ZX09501-004-001-008, 2015ZX09501004-001-002]; National TCM Industry Science and Technology Program [201507004-04]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81373984, 81403126]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7152142]
第一作者单位：[1]Department of Integrative Medicine, Medical School of Chinese PLA, Beijing, China[2]Division of Integrative Medicine, Beijing 302 Hospital, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Integrative Medicine, Medical School of Chinese PLA, Beijing, China[4]Institute of Chinese Herbal Medicine, Beijing 302 Hospital, Beijing, China
推荐引用方式(GB/T 7714)：
Jing Jing,Wang Rui-lin,Zhao Xin-yan,et al.Association between the concurrence of pre-existing chronic liver disease and worse prognosis in patients with an herb- Polygonum multiflorum thunb. induced liver injury: a case-control study from a specialised liver disease center in China[J].BMJ OPEN.2019,9(1):doi:10.1136/bmjopen-2018-023567.
APA：
Jing, Jing,Wang, Rui-lin,Zhao, Xin-yan,Zhu, Yun,Niu, Ming...&Wang, Jia-bo.(2019).Association between the concurrence of pre-existing chronic liver disease and worse prognosis in patients with an herb- Polygonum multiflorum thunb. induced liver injury: a case-control study from a specialised liver disease center in China.BMJ OPEN,9,(1)
MLA：
Jing, Jing,et al."Association between the concurrence of pre-existing chronic liver disease and worse prognosis in patients with an herb- Polygonum multiflorum thunb. induced liver injury: a case-control study from a specialised liver disease center in China".BMJ OPEN 9..1(2019)
