单位：[1]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, China [2]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou 350025, China [3]National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China 首都医科大学附属北京友谊医院[4]Fuzhou Center for Disease Control and Prevention, Fuzhou 350004, China [5]Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350108, China [6]Liver Disease Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China
Background. Some studies showed that microRNA-497 (miR-497) might act as a prognostic biomarker of cancer. However, the conclusion was not consistent. The aim of this study was to investigate the prognostic role of miR-497 in various carcinomas. Methods. We systematically searched the databases of PubMed, Embase, Web of Science, Chinese National Knowledge Infrastructure (CNKI), and Wanfang Data to identify relevant studies. Two independent reviewers performed the data extraction and assessed the study quality. Hazard ratios (HRs) with corresponding 95% confidence intervals (CIs) for overall survival (OS) and disease-free survival/relapse-free survival (DFS/RFS) were used to assess the associations between miR-497 expression and cancer prognosis. Results. A total of 15 studies involving 1760 participants fulfilled the inclusion criteria. The lower level of miR-497 expression was significantly associated with shorter overall survival (HR=2.19, 95% CI: 1.84-2.60). No significant association was found between miR-497 expression and DFS/RFS in various carcinomas (HR=1.17, 95% CI: 0.53-2.57). Subgroup analyses by ethnicity and cancer type showed the consistent results. Conclusion. Our studies suggested that miR-497 might be a prognostic biomarker in cancers. However, further multicenter prospective clinical researches are needed to confirm the association between miR-497 expression and cancer prognosis.
基金：
Natural Science Foundation of Fujian Province of ChinaNatural Science Foundation of Fujian Province [2016J01417]; Science and Technology Foundation of Fuzhou City [2015-S-143-19]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|3 区医学
小类|3 区生物工程与应用微生物3 区病理学4 区遗传学4 区医学：研究与实验
最新[2025]版：
无
JCR分区：
出版当年[2017]版：
Q2BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ2GENETICS & HEREDITYQ2MEDICINE, RESEARCH & EXPERIMENTALQ2PATHOLOGY
第一作者单位：[1]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, China [2]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou 350025, China
通讯作者：
通讯机构：[1]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, China [2]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou 350025, China [6]Liver Disease Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China
推荐引用方式(GB/T 7714)：
Liu Zhiqiang,Wu Shanshan,Wang Lei,et al.Prognostic Value of MicroRNA-497 in Various Cancers: A Systematic Review and Meta-Analysis[J].DISEASE MARKERS.2019,2019:doi:10.1155/2019/2491291.
APA：
Liu, Zhiqiang,Wu, Shanshan,Wang, Lei,Kang, Shuling,Zhao, Bixing...&Liu, Jingfeng.(2019).Prognostic Value of MicroRNA-497 in Various Cancers: A Systematic Review and Meta-Analysis.DISEASE MARKERS,2019,
MLA：
Liu, Zhiqiang,et al."Prognostic Value of MicroRNA-497 in Various Cancers: A Systematic Review and Meta-Analysis".DISEASE MARKERS 2019.(2019)
