Network pharmacology based investigation into the effect and mechanism of Modified Sijunzi Decoction against the subtypes of chronic atrophic gastritis
单位：[1]Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, 100700, China[2]Beijing University of Chinese Medicine, Beijing, 100029, China[3]The Biomedical Sciences Institute of Qingdao University (Qingdao Branch of SJTU Bio-X Institutes), Qingdao University, Qingdao, 266071, China[4]Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China[5]State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, China[6]Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China首都医科大学附属北京友谊医院
Chronic atrophic gastritis (CAG) is a common digestive disease without specific treatment. According to syndrome differentiation, traditional Chinese medicine (TCM) classified it into different syndromes and has achieved significant therapeutic effects. In this study, immune repertoire sequencing techniques combined with symptom scores, electronic gastroscopy as well as pathologic changes were used to evaluate the effect and the underlying mechanism of Modified Sijunzi Decoction (MSD) in treating CAG. The results showed that MSD could relieve CAG symptoms, improve pathologic changes in CAG with fatigue and tiredness symptom, but with no help in CAG with reversal heat symptom. Moreover, MSD could regulate immune disorders in CAG with fatigue and tiredness symptom, and 7 TCR biomarkers were explored in CAG patients with immune disorders. All these results indicated that MSD is effective in treating CAG patients with fatigue and tiredness symptom by tonifying the spleen qi, suggesting that CAG treatment based on syndrome differentiation is reasonable.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81522051]; National Key RAMP;D Program of China [2017YFC1700106]
第一作者单位：[1]Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, 100700, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Tian Guihua,Wu Chuanhong,Li Jian,et al.Network pharmacology based investigation into the effect and mechanism of Modified Sijunzi Decoction against the subtypes of chronic atrophic gastritis[J].PHARMACOLOGICAL RESEARCH.2019,144:158-166.doi:10.1016/j.phrs.2019.04.012.
APA：
Tian, Guihua,Wu, Chuanhong,Li, Jian,Liang, Bilin,Zhang, Feilong...&Chen, Jianxin.(2019).Network pharmacology based investigation into the effect and mechanism of Modified Sijunzi Decoction against the subtypes of chronic atrophic gastritis.PHARMACOLOGICAL RESEARCH,144,
MLA：
Tian, Guihua,et al."Network pharmacology based investigation into the effect and mechanism of Modified Sijunzi Decoction against the subtypes of chronic atrophic gastritis".PHARMACOLOGICAL RESEARCH 144.(2019):158-166
医学