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Downregulation of RPS15A by miR-29a-3p attenuates cell proliferation in colorectal carcinoma

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收录情况： ◇ SCIE ◇ EI

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单位： [1]Department of Medical Service, Zhangjiakou First Hospital, Zhangjiakou, Hebei Province, China [2]Department of Oncology, Zhangjiakou First Hospital, Zhangjiakou, Hebei Province, China [3]Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Disease, Beijing, China

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关键词： Colorectal carcinoma miR-29a-3p RPS15A cell cycle apoptosis

摘要：

miR-29a-3p has been reported to function as a tumor suppressor in several cancers. However, the biological function role of miR-29a-3p in colorectal carcinoma (CRC) has not been well investigated. In this study, we found that miR-29a-3p was at lower level expression in CRC tissues and cell lines. Experimental up-regulation miR-29a-3p with mimic could inhibit cell proliferation, but induced cell cycle arrest at G0/G1 phase and apoptosis in CRC cells. MiR-29a-3p overexpression significantly down-regulated the expression levels of CDK4, Cyclin D1, and Bax, but up-regulated the expression levels of p21 and Bcl-2 in DLD-1 cells. Moreover, ribosomal protein S15A (RPS15A) was predicted and confirmed as a direct target gene of miR-29a-3p. Furthermore, restoration of RPS15A could rescue the phenotypic changes caused by miR-29a-3p. The findings demonstrate miR-29a-3p inhibits CRC cell function possibly by targeting RPS15A, which might be exploited therapeutically in CRC.

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出版当年[2018]版：

大类 | 4 区生物

小类 | 4 区生化与分子生物学 4 区生物工程与应用微生物 4 区应用化学 4 区食品科技

最新[2025]版：

大类 | 4 区生物学

小类 | 4 区生化与分子生物学 4 区生物工程与应用微生物 4 区应用化学 4 区食品科技

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出版当年[2017]版：

Q3 FOOD SCIENCE & TECHNOLOGY Q3 CHEMISTRY, APPLIED Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q3 CHEMISTRY, APPLIED Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q4 FOOD SCIENCE & TECHNOLOGY

影响因子： 最新[2023版] 1.4 最新五年平均[2021-2025] 1.9 出版当年[2017版] 1.255 出版当年五年平均[2013-2017] 1.291 出版前一年[2016版] 1.295 出版后一年[2018版] 1.297

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第一作者单位： [1]Department of Medical Service, Zhangjiakou First Hospital, Zhangjiakou, Hebei Province, China

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