单位：[1]Department of Oncology, Beijing Friendship Hospital, Capital Medical University, Beijing, China临床科室肿瘤中心肿瘤内科首都医科大学附属北京友谊医院[2]Department of Oncology, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan Province, China[3]Department of Pathology, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan Province, China[4]Department of Surgery, Beijing Changping District Hospital of Traditional Medicine, Beijing, China[5]Department of Gynecology, Beijing Changping District Hospital of Traditional Medicine, Beijing, China[6]Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX, United States of America
Objective. To explore the association between the degree of fibrosis in fibrotic focus (FF) and the unfavorable clinicopathological prognostic features of breast cancer. Methods. A total of 169 cases of breast invasive ductal carcinoma (IDC) were included in the study. Hematoxylin and eosin (H&E) staining was performed in the primary lesion of breast IDC and the degree of fibrosis in tumor-stromal FF was assessed. The association between the degree of fibrosis in FF and the well-known clinicopathologic features of breast cancer was investigated and the influence of the degree of fibrosis in FF on the survival was analyzed. Results. Tumor size >2 cm (P = 0.023), vascular invasion (P = 0.011), lymphatic vessel invasion (P < 0.001) and HER-2+ (P = 0.032) were positively correlated with the degree of fibrosis in FF in breast IDC. The result of multivariate analysis showed that lymphatic vessel invasion was the only independent correlation factor of high fibrosis in FF in breast IDC (OR = 3.82, 95% CI[1.13 similar to 12.82], P = 0.031). The Nottingham prognostic index (NPI) of high fibrosis in FF was significantly higher than that of mild and moderate fibrosis in FF in the no vascular infiltration subgroup, the no nerve infiltration subgroup, and the Luminal A subgroup (P = 0.014, 0.039, and 0.018; respectively). Conclusions. The high fibrosis in FF is closely associated with the strong invasiveness and the high malignancy of breast IDC. The degree of fibrosis in FF might be considered as a very practical and meaningful pathological feature of breast cancer. Conclusions. The high fibrosis in FF is closely associated with the strong invasiveness and the high malignancy of breast IDC. The degree of fibrosis in FF might be considered as a very practical and meaningful pathological feature of breast cancer.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81301912]; Beijing Municipal Health System High-level Health Person Foundation Project [2014-3-005]; Beijing Municipal Science and Technology Commission Foundation [Z161100000516083]
第一作者单位：[1]Department of Oncology, Beijing Friendship Hospital, Capital Medical University, Beijing, China[2]Department of Oncology, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan Province, China
通讯作者：
推荐引用方式(GB/T 7714)：
Li Yongfu,Wei Yuhan,Tang Wenjun,et al.Association between the degree of fibrosis in fibrotic focus and the unfavorable clinicopathological prognostic features of breast cancer[J].PEERJ.2019,7:doi:10.7717/peerj.8067.
APA：
Li, Yongfu,Wei, Yuhan,Tang, Wenjun,Luo, Jingru,Wang, Minghua...&Li, Qin.(2019).Association between the degree of fibrosis in fibrotic focus and the unfavorable clinicopathological prognostic features of breast cancer.PEERJ,7,
MLA：
Li, Yongfu,et al."Association between the degree of fibrosis in fibrotic focus and the unfavorable clinicopathological prognostic features of breast cancer".PEERJ 7.(2019)
