单位：[1]Department of Psychiatry, Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang, 325000, China[2]Department of Biochemistry and Molecular Biology, Zhengzhou University, Zhengzhou, Henan, 450001, China[3]Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, China,[4]MDT Center for Cognitive Impairment and Sleep Disorders, First Hospital of Shanxi Medical University, Taiyuan, China[5]National Key Disciplines, Key Laboratory for Cellular Physiology, Ministry of Education, Department of Neurobiology, Shanxi Medical University, Taiyuan, Shanxi 030001, China[6]Department of Psychiatry, School of Mental Health, Psychiatric Genetics Laboratory (PSYG-Lab), Jining Medical University, Jining, Shandong, 272191, China[7]Department of Psychiatry, Linyi Mental Health Center, Linyi, Shandong, 271000, China[8]Department of Psychiatric-Neuroimaging-Genetics and Morbidity Laboratory (PNGC-Lab), Nankai University Affiliated Anding Hospital, Tianjin Mental Health Center, Mental Health Teaching Hospital, Tianjin Medical University, Tianjin 300222, China[9]Department of China-Canada Biological Psychiatry Lab, Xiamen Xianyue Hospital, Xiamen, Fujian, 361000, China[10]National Integrated Traditional and Western Medicine Center for Cardiovascular Disease, China-Japan Friendship Hospital, Beijing, 100029, China
Sudden cardiac death (SCD) is relatively uncommon, yet it is a deadly consequence of some antipsychotic medications in patients with psychiatric disorders. The widespread concerns about the adverse cardiac effects associated with antipsychotics and their unpredictable nature have led to a restriction on the use of some antipsychotic medications. Recent progress has been made in the identification of important genetic factors that may contribute to the adverse complication of antipsychotic drugs, suggesting that high-risk individuals can be identified prior to initiating therapy. In addition, some high-tech smart wearable medical devices have recently been developed, allowing users to record and analyze the electrocardiogram (ECG) in couple with artificial intelligence (AI) technologies, and notifying of irregular heart rhythms or arrhythmias, a medical condition well documented in most SCD cases. In this literature review, we summarize recent advances in understanding the link between SCD and antipsychotic drug usage, as well as in utilizing wearable medical devices for monitoring of cardiac arrhythmias. New strategies for improving the care of patients receiving antipsychotic medications are proposed. As it is now possible to evaluate the risk of SCD in patients on antipsychotic medications, preventative measures and close monitoring may be used to detect the early signs of adverse cardiac events and SCD.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81871052]; Key Projects of Natural Science Foundation of Tianjin, China [17JCZDJC35700]; Tianjin Health Bureau Foundation [2014KR02]; Wenzhou Science and Technology Project [ZS2017011]
第一作者单位：[1]Department of Psychiatry, Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang, 325000, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Psychiatry, Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang, 325000, China[2]Department of Biochemistry and Molecular Biology, Zhengzhou University, Zhengzhou, Henan, 450001, China[6]Department of Psychiatry, School of Mental Health, Psychiatric Genetics Laboratory (PSYG-Lab), Jining Medical University, Jining, Shandong, 272191, China[8]Department of Psychiatric-Neuroimaging-Genetics and Morbidity Laboratory (PNGC-Lab), Nankai University Affiliated Anding Hospital, Tianjin Mental Health Center, Mental Health Teaching Hospital, Tianjin Medical University, Tianjin 300222, China[9]Department of China-Canada Biological Psychiatry Lab, Xiamen Xianyue Hospital, Xiamen, Fujian, 361000, China[*1]Department of Psychiatry, Institute of Mental Health, Psychiatric Genetics Laboratory (PSYG-Lab), Jining Medical University, Jining, Shandong 272191, China
推荐引用方式(GB/T 7714)：
Zhu Jingjing,Hou Weihong,Xu Yong,et al.Antipsychotic drugs and sudden cardiac death: A literature review of the challenges in the prediction, management, and future steps[J].PSYCHIATRY RESEARCH.2019,281:doi:10.1016/j.psychres.2019.112598.
APA：
Zhu, Jingjing,Hou, Weihong,Xu, Yong,Ji, Feng,Wang, Guowei...&Shao, Mingjng.(2019).Antipsychotic drugs and sudden cardiac death: A literature review of the challenges in the prediction, management, and future steps.PSYCHIATRY RESEARCH,281,
MLA：
Zhu, Jingjing,et al."Antipsychotic drugs and sudden cardiac death: A literature review of the challenges in the prediction, management, and future steps".PSYCHIATRY RESEARCH 281.(2019)
