单位：[1]Graduate School, Beijing University of Chinese Medicine, Beijing, China,[2]Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China,[3]Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China,[4]State Key Laboratory of Resources and Environmental Information System, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, China,[5]Institute of Child and Adolescent Health and School of Public Health, Peking University, Beijing, China
Backgrounds and Objectives: The north-south height distinctions in Chinese children suggest that some geographical-climatic factors could determine height variation of short stature. In a national health survey, we aimed to explore the spatial distribution of short stature on city scales, and detect its socio-economic and geographical-climatic factors. Methods: Data on the prevalence of short stature were obtained from a 2014 cross-sectional survey of China (CNSSCH). In total, 213,795 Han Chinese students aged 7-18 years, from 106 cities across 30 provinces, were included. Both China and World Health Organization (WHO) growth references were adopted to define short stature. Results: A spatial clustering was apparent in the distribution of short stature. After multivariable adjustment, altitude and humidity significantly increased the risk of high prevalence in short stature, according to the WHO (odds ratio [OR] = 1.61 and 1.26, 95% confidence interval [CI]: 1.20-2.17 and 1.03-1.54) and China (OR = 1.54 and 1.26; 95% CI: 1.15-2.05 and 1.02-1.55) growth references. Additionally, education significantly decreased the risk of high prevalence in short stature according to the WHO (OR = 0.40; 95% CI: 0.22-0.74) and China (OR = 0.42; 95% CI: 0.22-0.77) growth references. Combining both altitude >400 m and education <9 years, as well as education <9 years and humidity >70%, received the largest effect-size estimate, and significance retained after multivariable adjustment. Conclusions: Our findings indicate that high altitude and humidity increased the risk of high prevalence in short stature, high education was associated with low prevalence. Additionally, we observed possible interactions between education and altitude/humidity. They may interactively explain spatial discrepancy and predict short stature in Chinese school children. Further validations are necessary.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [41525004, 41571376]
第一作者单位：[1]Graduate School, Beijing University of Chinese Medicine, Beijing, China,[2]Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China,
共同第一作者：
通讯作者：
通讯机构：[5]Institute of Child and Adolescent Health and School of Public Health, Peking University, Beijing, China
推荐引用方式(GB/T 7714)：
Ma Jia,Zhang Zhixin,Niu Wenquan,et al.Education, Altitude, and Humidity Can Interactively Explain Spatial Discrepancy and Predict Short Stature in 213,795 Chinese School Children[J].FRONTIERS in PEDIATRICS.2019,7:doi:10.3389/fped.2019.00425.
APA：
Ma, Jia,Zhang, Zhixin,Niu, Wenquan,Chen, Jie,Guo, Sihui...&Pei, Tao.(2019).Education, Altitude, and Humidity Can Interactively Explain Spatial Discrepancy and Predict Short Stature in 213,795 Chinese School Children.FRONTIERS in PEDIATRICS,7,
MLA：
Ma, Jia,et al."Education, Altitude, and Humidity Can Interactively Explain Spatial Discrepancy and Predict Short Stature in 213,795 Chinese School Children".FRONTIERS in PEDIATRICS 7.(2019)
