单位：[1]Department of Orthopedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.[2]Department of Orthopedic, Air Force General Hospital of the Chinese People’s Liberation Army, Beijing, China.[3]Department of Plastic Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.[4]Department of Orthopedics, Beijing Friendship Hospital, Capital Medical University, Beijing, China.临床科室骨科骨科首都医科大学附属北京友谊医院[5]Beijing Key Laboratory for Genetic Research of Skeletal Deformity, Beijing, China.
The overall objective of this study was to test the hypothesis that +Gz (hypergravity/positive acceleration) and microgravity can both aggravate intervertebral disc degeneration (IVDD). Due to +Gz and microgravity, many pilots develop IVDD. However, the lack of animal models of IVDD under conditions of simulated +Gz and microgravity has hampered research on the onset and prevention of IVDD. Rabbits were randomly allotted to a control group, microgravity group, +Gz group, or mixed (+Gz microgravity) group. A tail-suspension model was utilized to simulate a microgravity environment and an animal centrifuge to mimic +Gz conditions. After exposure to the above conditions for 4, 8, and 24 weeks, the body weights (BW) of animals in the control group gradually increased overtime, while those of animals in the microgravity and mixed groups both decreased (p < 0.001). As compared with the control group, the proteoglycan content of animals in the other three groups was significantly reduced (F= 192.83, p < 0.001). The imageological, histopathological, and immunohistochemical changes to the L6-S1 intervertebral disc samples suggests that the effects of +Gz and microgravity can aggravate IVDD overtime. The mixed effects of +Gz and microgravity had the greatest effect on degeneration and +Gz had a particularly greater effect than microgravity.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81171741]
第一作者单位：[1]Department of Orthopedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
通讯作者：
推荐引用方式(GB/T 7714)：
Di Wu,Xi Zhou,Chao Zheng,et al.The effects of simulated plus Gz and microgravity on intervertebral disc degeneration in rabbits[J].SCIENTIFIC REPORTS.2019,9:doi:10.1038/s41598-019-53246-7.
APA：
Di Wu,Xi Zhou,Chao Zheng,Yu He,Lingjia Yu...&Yong Liu.(2019).The effects of simulated plus Gz and microgravity on intervertebral disc degeneration in rabbits.SCIENTIFIC REPORTS,9,
MLA：
Di Wu,et al."The effects of simulated plus Gz and microgravity on intervertebral disc degeneration in rabbits".SCIENTIFIC REPORTS 9.(2019)
