单位：[1]China-Japan Friendship School of Clinical Medicine, Peking University, No.2 Yinghua East Street, Beijing 100029, China[2]Beijing University of Chinese Medicine, Yinghua East Street, Beijing 100029, China[3]Department of Orthopedic Surgery, Beijing Key Lab Immune-Mediated Inflammatory Diseases, China-Japan Friendship Hospital, No.2 Yinghua East Street, Beijing ,100029, China.
Background: Knee osteoarthritis is a joint disease which is characterized by degeneration of articular cartilage and subsequent subchondral bone changes. Polymorphisms of IL-17A/F gene were the recognized candidate genes associated with knee osteoarthritis risk although the results were conflicting. The aim of this study was to determine whether IL-17A(rs2275913) and IL-17F(rs763780) polymorphisms confer susceptibility to knee osteoarthritis. Method: Literature search was performed in PubMed, Medline, Cochrane Library, Web of science, Embase, and Google Scholar (last search was updated on June 20, 2019), and assessing this association was performed by calculating odds ratios with 95% confidence intervals. Statistical heterogeneity was quantitatively evaluated by using the Q statistic with its p value and I-2 statistic. Result: Six case-control based studies were included involving IL-17A(rs2275913) (2134 cases and 2306 controls) and IL-17F(rs763780) (2134 cases and 2426 controls). The overall analysis suggested that the A allele of the rs2275913 polymorphism, and the C allele of the rs763780 polymorphism in the IL-17 gene may increase the risk of OA. However, subgroup analysis revealed that no association between IL-17A(rs2275913) gene and knee OA risk was found in Caucasian population. Conclusions: This meta-analysis revealed that the IL-17A(rs2275913) gene polymorphisms may increase the risk of knee OA in Asians, and the IL-17F(rs763780) gene polymorphisms may increase the risk of knee OA both in Asians and Caucasians. However, because of the limitations of the present study, additional larger studies are needed to confirm our findings in the future.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81703896, 81673776]; Beijing municipal science and technology commissionBeijing Municipal Science & Technology Commission [Z171100001017209]; Capital Health Research and Development of Special [2016-2-4062]
第一作者单位：[1]China-Japan Friendship School of Clinical Medicine, Peking University, No.2 Yinghua East Street, Beijing 100029, China
通讯作者：
推荐引用方式(GB/T 7714)：
Lu Feifan,Liu Pei,Zhang Qidong,et al.Association between the polymorphism of IL-17A and IL-17F gene with knee osteoarthritis risk: a meta-analysis based on case-control studies[J].JOURNAL of ORTHOPAEDIC SURGERY and RESEARCH.2019,14(1):doi:10.1186/s13018-019-1495-0.
APA：
Lu, Feifan,Liu, Pei,Zhang, Qidong,Wang, Weiguo&Guo, Wanshou.(2019).Association between the polymorphism of IL-17A and IL-17F gene with knee osteoarthritis risk: a meta-analysis based on case-control studies.JOURNAL of ORTHOPAEDIC SURGERY and RESEARCH,14,(1)
MLA：
Lu, Feifan,et al."Association between the polymorphism of IL-17A and IL-17F gene with knee osteoarthritis risk: a meta-analysis based on case-control studies".JOURNAL of ORTHOPAEDIC SURGERY and RESEARCH 14..1(2019)
