单位：[1]Liver Transplantation Center, National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, China临床科室国家中心普外分中心普外四科（肝脏移植外科）首都医科大学附属北京友谊医院[2]Department of Hepatobiliary and Pancreatic Surgery, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi Province, China[3]Beijing Key Laboratory of Tolerance Induction and Organ Protection in Transplantation, Beijing Friendship Hospital, Capital Medical University, Beijing, China首都医科大学附属北京友谊医院
Background. The use of pediatric donor liver for pediatric liver transplantation (LT) remains controversial and few studies have focused on pediatric deceased donors. To address this issue, we decided to perform a retrospective research, trying to compare the clinical effects between deceased donor LTs (DDLTs) and living donor LTs (LDLTs). Methods. A retrospective review of pediatric LTs using grafts from deceased donors and living donors from June 2013 to August 2016 was performed. The children were divided into a DDLT group and a LDLT group based on their donor styles. The incidence of early vascular complications (VC), biliary complications, and graft and patient survival rates were observed between the 2 groups. Results. There were 217 cases of pediatric LTs performed in our hospital from June 2013 to August 2016 (83 DDLTs and 134 LDLTs). The 1-year cumulative survival rates of grafts and recipients were 89.16% and 91.57% in DDLTs, and 95.47% and 95.52% in LDLTs, respectively (P > .05). The incidence of early VC was lower in LDLTs than that in DDLTs (3.7% vs 19.3%, P < .001). The incidence of HAT in children aged less than 1 year was significantly higher in the DDLT group (P < .001) and can be up to 31.82%. The incidence of biliary complications was similar in the 2 groups (8.4% vs 13.5%, P = .285). Conclusions. Pediatric DDLTs have similar graft and patient survival rates with LDLT. The incidence of early VC was higher in DDLTs, and children aged less than 1 year are at a higher risk of developing HAT.
基金：
National Key Technologies RD ProgramNational Key Technology R&D Program [2015BAI13B09]; Scientific Research Key Program of Beijing Municipal Commission of EducationBeijing Municipal Commission of Education [KZ201510025026]
第一作者单位：[1]Liver Transplantation Center, National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, China[2]Department of Hepatobiliary and Pancreatic Surgery, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi Province, China
通讯作者：
通讯机构：[1]Liver Transplantation Center, National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, China[3]Beijing Key Laboratory of Tolerance Induction and Organ Protection in Transplantation, Beijing Friendship Hospital, Capital Medical University, Beijing, China[*1]Liver Transplantation Center, Beijing Friendship Hospital, Capital Medical University, No. 95 Yongan Road, Beijing 100050, China
推荐引用方式(GB/T 7714)：
Zhang R.,Zhu Z. -J.,Sun L. -Y.,et al.Outcomes of Pediatric Liver Transplantation: Deceased Donor Liver Transplantation vs Living Donor Liver Transplantation[J].TRANSPLANTATION PROCEEDINGS.2018,50(10):3601-3605.doi:10.1016/j.transproceed.2018.04.035.
APA：
Zhang, R.,Zhu, Z. -J.,Sun, L. -Y.,Wei, L.,Qu, W....&Liu, Y..(2018).Outcomes of Pediatric Liver Transplantation: Deceased Donor Liver Transplantation vs Living Donor Liver Transplantation.TRANSPLANTATION PROCEEDINGS,50,(10)
MLA：
Zhang, R.,et al."Outcomes of Pediatric Liver Transplantation: Deceased Donor Liver Transplantation vs Living Donor Liver Transplantation".TRANSPLANTATION PROCEEDINGS 50..10(2018):3601-3605
