单位：[1]Department of Gastroenterology, The People’s Hospital of Yichun City, Yichun, China[2]Department of Dermatology, Beijing Hospital of Traditional Chinese Medicine, Beijing, China[3]Department of General Surgery, First Affiliated Hospital of Gannan Medical College, Ganzhou, China[4]Department of Gastroenterology, China-Japan Friendship Hospital, Beijing, China
Matrine may be protective against colorectal cancer (CRC), but how it may work is unclear. Thus, we explored the underlying mechanisms of matrine in CRC. Matrine-related proteins and CRC-related genes and therapeutic targets of matrine in CRC were predicted using a network pharmacology approach. Five targets, including interleukin 6 (IL-6), the 26S proteasome, tumor necrosis factor alpha (TNF-alpha), transforming growth factor beta 1 (TGF-beta 1) and p53, and corresponding high-mobility group box 1 (HMGB1) signaling and T helper cell differentiation were thought to be associated with matrine's mechanism. Expression of predicted serum targets were verified in a 1,2-dimethylhydrazine dihydrochloride-induced CRC model rats that were treated with matrine (ip) for 18 weeks. Data show that matrine suppressed CRC growth and decreased previously elevated expression of IL-6, TNF-alpha, p53, and HMGB1. Matrine may have had a therapeutic effect on CRC via inhibition of HMGB1 signaling, and this occurred through downregulation of IL-6, TNF-alpha, and HMGB1.
基金：
National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81360606]; China Scholarship Council fundChina Scholarship Council [201609110029]; China-Japan Friendship Hospital Research funding [2016-1-MS-5]; National High Technology Research and Development Program of China (863 programs)National High Technology Research and Development Program of China [2014AA020801]
第一作者单位：[1]Department of Gastroenterology, The People’s Hospital of Yichun City, Yichun, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Huizhen Fan,Chunyan Jiang,Baoyuan Zhong,et al.Matrine Ameliorates Colorectal Cancer in Rats via Inhibition of HMGB1 Signaling and Downregulation of IL-6, TNF-alpha, and HMGB1[J].JOURNAL of IMMUNOLOGY RESEARCH.2018,2018:doi:10.1155/2018/5408324.
APA：
Huizhen Fan,Chunyan Jiang,Baoyuan Zhong,Jianwen Sheng,Ting Chen...&Hongchuan Zhao.(2018).Matrine Ameliorates Colorectal Cancer in Rats via Inhibition of HMGB1 Signaling and Downregulation of IL-6, TNF-alpha, and HMGB1.JOURNAL of IMMUNOLOGY RESEARCH,2018,
MLA：
Huizhen Fan,et al."Matrine Ameliorates Colorectal Cancer in Rats via Inhibition of HMGB1 Signaling and Downregulation of IL-6, TNF-alpha, and HMGB1".JOURNAL of IMMUNOLOGY RESEARCH 2018.(2018)
