Objective This study was performed to investigate impaired vagal activity to meal in patients with functional dyspepsia (FD) with delayed gastric emptying (GE). Methods Eighty-five patients were studied. GE parameters, including those in the overall and proximal stomach, were measured by GE functional tests at the Department of Nuclear Medicine. Autonomic nervous function was tested by spectral analysis of heart rate variability (HRV). The vagal activity and sympathetic activity were analyzed by recording the power in the high-frequency component (HF), low-frequency component (LF), and LF/HF ratio. Results Overall and proximal GE were delayed in 47.2% and 50.9% of the patients, respectively. Spectral analysis of HRV showed that the HF in patients with delayed proximal GE was significantly lower and that the LF/HF ratio was significantly higher than those in patients with normal proximal GE after a meal. Conclusion Delayed proximal GE might be caused by disrupted sympathovagal balance as a result of decreased vagal activity after a meal. Improvement in vagal activity may constitute an effective treatment method for patients with FD.
基金：
National Key Technology R&D Program in the 12th 5-Year Plan of ChinaNational Key Technology R&D Program [2014BAI08B02]
语种：
外文
被引次数：
WOS：
中科院(CAS)分区：
出版当年[2017]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
最新[2025]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
JCR分区：
出版当年[2016]版：
Q4MEDICINE, RESEARCH & EXPERIMENTALQ4PHARMACOLOGY & PHARMACY
最新[2023]版：
Q4MEDICINE, RESEARCH & EXPERIMENTALQ4PHARMACOLOGY & PHARMACY
第一作者单位：[1]Department of Gastroenterology, China-Japan Friendship Hospital, Beijing, China
通讯作者：
通讯机构：[1]Department of Gastroenterology, China-Japan Friendship Hospital, Beijing, China[*1]Department of Gastroenterology, China-Japan Friendship Hospital, 2 Yinghua East Road, Beijing 100029, China.
推荐引用方式(GB/T 7714)：
W-J Guo,S-K Yao,Y-L Zhang,et al.Impaired vagal activity to meal in patients with functional dyspepsia and delayed gastric emptying[J].JOURNAL of INTERNATIONAL MEDICAL RESEARCH.2018,46(2):792-801.doi:10.1177/0300060517726442.
APA：
W-J Guo,S-K Yao,Y-L Zhang,S-Y Du,H-F Wang...&H-L Li.(2018).Impaired vagal activity to meal in patients with functional dyspepsia and delayed gastric emptying.JOURNAL of INTERNATIONAL MEDICAL RESEARCH,46,(2)
MLA：
W-J Guo,et al."Impaired vagal activity to meal in patients with functional dyspepsia and delayed gastric emptying".JOURNAL of INTERNATIONAL MEDICAL RESEARCH 46..2(2018):792-801
