单位：[1]Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China首都医科大学附属北京友谊医院[2]Beijing Center for Physical and Chemical Analysis, Beijing 100089, China[3]Department of Biological Sciences, Southeastern Oklahoma State University, Durant, OK 74701, USA[4]School of Food and Bioengineering, Henan University of Science and Technology, Luoyang, Henan 471023, China.
The Spindle- and Kinetochore-Associated (SKA) complex has been proven to be involved in many human mental behavioral disorders. Glucocorticoid, a hypothalamic-pituitary-adrenal (HPA) axis hormone, is a critical mediator of stress response in neurons. However, the underlying mechanisms of glucocorticoid's effects on human neuronal cells remain unclear. This study demonstrates that increased extracellular glucocorticoid levels significantly reduce neuronal cell SKA complex genes' expression levels, followed by altered neuronal cell viability and neurite development. The results suggest that the abnormality of this HPA-axis hormone could impact the neuronal cell functions through the alternation of SKA complex functions, which might induce cell death.
基金：
National Natural Science Foundations of ChinaNational Natural Science Foundation of China (NSFC) [81450029]; Beijing Academy of Science and Technology Key Projects Funding [20130-12]; Southeastern Faculty Research Grant [A-6-0502-1612-005]
