单位：[1]Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Diseases, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases, Beijing 100050, China临床科室国家中心消化分中心消化内科首都医科大学附属北京友谊医院[2]Department of Digestive Diseases, Affiliated Hospital forWei Fang Medical University,Wei Fang 261031, China[3]Key Laboratory of Safety Risk Assessment of Ministry of Health, China National Center for Food Safety Risk Assessment, Beijing 100021, China[4]Department of Ultrapathology of Beijing Neurosurgical Institute, Beijing 100050, China首都医科大学附属天坛医院[5]Department of Ultrapathology of Beijing Neurosurgical Institute, Affiliated Bayi Brain Hospital, Army General Hospital of PLA, Beijing 100700, China首都医科大学附属天坛医院[6]The Animal Experiment Center of Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China首都医科大学附属北京友谊医院
Bismuth-containing quadruple therapy has been recommended as the first line of treatment in areas of high clarithromycin or metronidazole resistance. However, safety concerns of bismuth agents have long been raised. We first assessed the efficacy and safety of Wei Bi Mei granules, which are bismuth compounds consisting of three synthetic drugs and five medicinal herbs, compared to bismuth aluminate and colloidal bismuth subcitrate (CBS) in H. pylori-infected mouse model. We then used atomic fluorescence spectroscopy and autometallography to measure the accumulation of three bismuth agents in the brain, heart, liver, and kidneys in adult Sprague-Dawley rats. We also evaluated the safety of bismuth agents by conducting clinical biochemistry tests in blood samples of experimental animals. Wei Bi Mei granules exhibited the highest efficacy of anti-H. pylori activity and yielded the lowest bismuth accumulation when compared to CBS and bismuth aluminate. Our findings show that Wei Bi Mei granules are a safe Chinese medicinal herb with potent anti-H. pylori activity and can be considered as an alternative to current bismuth compounds. Thus, Wei Bi Mei granules merit further evaluation, particularly with regard to efficacy and safety when they are combined with other H. pylori eradication medications in the clinical setting.
第一作者单位：[1]Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Diseases, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases, Beijing 100050, China[2]Department of Digestive Diseases, Affiliated Hospital forWei Fang Medical University,Wei Fang 261031, China
通讯作者：
推荐引用方式(GB/T 7714)：
Li Lei,Meng FanDong,Zhu Shengtao,et al.Efficacy and Safety of Wei Bi Mei, a Chinese Herb Compound, as an Alternative to Bismuth for Eradication of Helicobacter pylori[J].EVIDENCE-BASED COMPLEMENTARY and ALTERNATIVE MEDICINE.2018,2018:doi:10.1155/2018/4320219.
APA：
Li, Lei,Meng, FanDong,Zhu, Shengtao,Guo, ShuiLong,Wang, YongJun...&Zhang, ShuTian.(2018).Efficacy and Safety of Wei Bi Mei, a Chinese Herb Compound, as an Alternative to Bismuth for Eradication of Helicobacter pylori.EVIDENCE-BASED COMPLEMENTARY and ALTERNATIVE MEDICINE,2018,
MLA：
Li, Lei,et al."Efficacy and Safety of Wei Bi Mei, a Chinese Herb Compound, as an Alternative to Bismuth for Eradication of Helicobacter pylori".EVIDENCE-BASED COMPLEMENTARY and ALTERNATIVE MEDICINE 2018.(2018)
