单位：[1]Clinical Laboratory, China-Japan Friendship Hospital, Beijing, China[2]Beijing Key Lab Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing, China[3]Department of Endocrinology, China-Japan Friendship Hospital, Beijing, China[4]Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
The aim of this study was to investigate the relationship between EPHX2 rs751141 (R287Q polymorphism) and diabetic nephropathy (DN) in Chinese type 2 diabetes (T2D). This case-control study explored the association between EPHX2 rs751141 and DN in a total of 870 Chinese T2D patients (406 T2D patients with DN and 464 T2D patients without DN). DNA was extracted from peripheral leukocytes of the patients and rs751141 was genotyped. The A allele frequency of rs751141 was significantly lower in DN patients (20.94%) compared with non-DN controls (27.8%) (P = 0 001), and the A allele of rs751141 was associated with a significantly lower risk of DN after adjustment for multiple covariates in the additive genetic model (OR = 0.68, 95% CI = 0.52-0.88, P = 0 004). Significant association between rs751141 and homocysteine (Hcy) level on the risk of DN was observed, indicating that in patients with the highest Hcy levels, the A allele showed marked association with lower risk of DN in all three genetic models. In conclusion, the A allele of exonic polymorphism in EPHX2 rs751141 is negatively associated with the incidence of DN in the Chinese T2D population, which could be modulated by Hcy level status.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81703892, 8162010803, 81473526]; China-Japan Friendship Hospital Youth Science and Technology Excellence Project [2015-QNYC-B-09]
语种：
外文
被引次数：
WOS：
中科院(CAS)分区：
出版当年[2017]版：
大类|3 区医学
小类|3 区内分泌学与代谢3 区医学：研究与实验
最新[2025]版：
大类|3 区医学
小类|3 区内分泌学与代谢3 区医学：研究与实验
JCR分区：
出版当年[2016]版：
Q2MEDICINE, RESEARCH & EXPERIMENTALQ3ENDOCRINOLOGY & METABOLISM
最新[2023]版：
Q2ENDOCRINOLOGY & METABOLISMQ2MEDICINE, RESEARCH & EXPERIMENTAL
第一作者单位：[1]Clinical Laboratory, China-Japan Friendship Hospital, Beijing, China
通讯作者：
推荐引用方式(GB/T 7714)：
Ma Liang,Yan Meihua,Kong Xiaomu,et al.Association of EPHX2 R287Q Polymorphism with Diabetic Nephropathy in Chinese Type 2 Diabetic Patients[J].JOURNAL of DIABETES RESEARCH.2018,2018:doi:10.1155/2018/2786470.
APA：
Ma, Liang,Yan, Meihua,Kong, Xiaomu,Jiang, Yongwei,Zhao, Tingting...&Li, Ping.(2018).Association of EPHX2 R287Q Polymorphism with Diabetic Nephropathy in Chinese Type 2 Diabetic Patients.JOURNAL of DIABETES RESEARCH,2018,
MLA：
Ma, Liang,et al."Association of EPHX2 R287Q Polymorphism with Diabetic Nephropathy in Chinese Type 2 Diabetic Patients".JOURNAL of DIABETES RESEARCH 2018.(2018)
