单位：[1]School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, PR China[2]Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing 100029, PR China[3]Department of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, PR China[4]School of Chinese Medicine Sciences, Beijing University of Chinese Medicine, Beijing 100029, PR China
A rare C-12-norabietane diterpene racemate (1) and a new abietane diterpene alkaloid (2) were isolated from the roots of Salvia miltiorrhiza Bunge. Their structures were established by comprehensive spectroscopic analyses, and 1 was successfully resolved by chiral HPLC, demonstrating that 1 is racemic. The absolute configurations of la [(+)-miltiorolide A], 1b [(-)-miltiorolide A], and 2 were determined using TDDFT-ECD calculations. la and lb are the first examples of enantiomeric C-12-norabietane diterpenes featuring an isobutylene with a tetrahydronaphthalene-butyrolactone ring system. The cytotoxic activities of the isolates (1 and 2) were evaluated against three human cancer cell lines BEL-7402, HT-29 and PANC-28. A plausible biogenetic pathway of 1 was also proposed.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81473119, 81473590, 81102343]; 'Ten Diseases & Ten Drugs' Project of Beijing Municipal Science & Technology Commission [Z171100001717009]
第一作者单位：[1]School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, PR China[2]Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing 100029, PR China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Pan Xue-Ge,He Jun,Wang Xiao-Xue,et al.An unusual racemic C-12-norabietane diterpene and a new abietane diterpene alkaloid from Salvia miltiorrhiza Bunge[J].FITOTERAPIA.2018,125:240-244.doi:10.1016/j.fitote.2017.12.004.
APA：
Pan, Xue-Ge,He, Jun,Wang, Xiao-Xue,Zhang, Jia,Ma, Bing-Zhi...&Xu, Jie-Kun.(2018).An unusual racemic C-12-norabietane diterpene and a new abietane diterpene alkaloid from Salvia miltiorrhiza Bunge.FITOTERAPIA,125,
MLA：
Pan, Xue-Ge,et al."An unusual racemic C-12-norabietane diterpene and a new abietane diterpene alkaloid from Salvia miltiorrhiza Bunge".FITOTERAPIA 125.(2018):240-244
