单位：[1]International Department, China-Japan Friendship Hospital, Beijing, China[2]Traditional Chinese Medicine Department, Beijing Tiantan Hospital, Beijing, China首都医科大学附属天坛医院[3]Brain Research Centre, University of British Columbia, Vancouver, Canada
Transactive response DNA-binding protein 43kD (TDP-43) is a major component of tau-negative and biquitin-positive inclusions that characterize ALS (amyotrophic lateral sclerosis) and FTLD (fronto-temporal lobar degeneration). Due to its central role in neurodegenerative disease pathogenesis, most research recently has focused on its role associated with neurodegeneration disease, research on neuron and glial cell showed that pathological TDP-43 is associated with cell apoptosis which lead to loss of functional neurons and glial cells. However, little is known about its role on cancer cells, here we report a 35kD fragment of TDP-43 also plays a key role in apoptosis of breast cancer cells, and may be served as a potential therapeutic target to cure cancer. (C) 2018 Elsevier Inc. All rights reserved.
基金：
Canadian Cancer SocietyCanadian Cancer Society (CCS); National Natural Science FoundationNational Natural Science Foundation of China (NSFC) [81072901]; Beijing Municipal Natural Science FoundationBeijing Natural Science Foundation [7174299]
第一作者单位：[1]International Department, China-Japan Friendship Hospital, Beijing, China
通讯作者：
通讯机构：[3]Brain Research Centre, University of British Columbia, Vancouver, Canada[*1]F233-2211,Wesbrook Mall, Vancouver, British Columbia, V6T 2B5, Canada
推荐引用方式(GB/T 7714)：
Nan Yinan,Wang Shaoqing,Jia William.Caspase independent cleavages of TDP-43 generates 35kD fragment that cause apoptosis of breast cancer cells[J].BIOCHEMICAL and BIOPHYSICAL RESEARCH COMMUNICATIONS.2018,497(1):51-57.doi:10.1016/j.bbrc.2018.01.190.
APA：
Nan, Yinan,Wang, Shaoqing&Jia, William.(2018).Caspase independent cleavages of TDP-43 generates 35kD fragment that cause apoptosis of breast cancer cells.BIOCHEMICAL and BIOPHYSICAL RESEARCH COMMUNICATIONS,497,(1)
MLA：
Nan, Yinan,et al."Caspase independent cleavages of TDP-43 generates 35kD fragment that cause apoptosis of breast cancer cells".BIOCHEMICAL and BIOPHYSICAL RESEARCH COMMUNICATIONS 497..1(2018):51-57
