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On-treatment changes of liver stiffness at week 26 could predict 2-year clinical outcomes in HBV-related compensated cirrhosis

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收录情况： ◇ SCIE

作者：
Wu, Shanshan[1] * ; Kong, Yuanyuan[1] ; Piao, Hongxin[2] ; Jiang, Wei[3] ; Xie, Wen[4] ; Chen, Yongpeng[5] ; Lu, Lungen[6] ; Ma, Anlin[7] ; Xie, Shibin[8] ; Ding, Huiguo[9] ; Shang, Jia[10] ; Zhang, Xuqing[11] ; Feng, Bo[12] ; Han, Tao[13] ; Xu, Xiaoyuan[14] ; Huo, Lijuan[15] ; Cheng, Jilin[16] ; Li, Hai[17] ; Wu, Xiaoning[1] ; Zhou, Jialing[1] ; Sun, Yameng[1] ; Ou, Xiaojuan[1] ; Zhang, Hui[18] ; You, Hong[1] ; Jia, Jidong[1,*1] ;
单位： [1]Liver Research Center, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis, National Clinical Research Center of Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, China [2]Infectious Department, Affiliated Hospital of Yanbian University, Yanji, China [3]Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai, China [4]Center of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China [5]Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China [6]Department of Gastroenterology and Hepatology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China [7]Department of Infectious Diseases, China-Japan Friendship Hospital, Beijing, China [8]Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China [9]Department of Gastroenterology and Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, China [10]Henan Provincial People’s Hospital, Zhengzhou, China [11]Department of Infectious Diseases, Southwest Hospital, Third Military Medical University of Chinese People’s Liberation Army, Chongqing, China [12]Hepatology Institute, Peking University People’s Hospital, Beijing, China [13]Department of Gastroenterology and Hepatology, Tianjin Third Central Hospital, Tianjin, China [14]Department of Infectious Disease, Peking University First Hospital, Beijing, China [15]First Hospital of Shanxi Medical University, Taiyuan, China [16]Department of Gastroenterology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China [17]Department of Hepatopancreatobiliary and Splenic Medicine, Affiliated Hospital, Logistics University of People’s Armed Police Force, Tianjin, China [18]Department of Biostatistics, St Jude Children’s Research Hospital, Memphis, TN, USA
出处：
DOI： 10.1111/liv.13623
ISSN：

关键词： dynamic change HBV-related compensated cirrhosis liver-related events liver stiffness

摘要：
Background & AimsIt is unclear whether liver stiffness measurement (LSM) dynamic changes after anti-HBV treatment could predict the risk of liver-related events (LREs), particularly in patients with HBV-related compensated cirrhosis. MethodsTreatment-naive patients with HBV-related compensated cirrhosis were enrolled. All patients were under entecavir-based antiviral therapy, and followed up every 26weeks for 2years. The association between LSM and LREs was analysed by Cox proportional hazard model and Harrell C-index analysis. ResultsA total of 438 patients were included in the study. At the follow-up of 104weeks, LREs developed in 33/438 (7.8%) patients, including 16 episodes of decompensation, 18 HCC and 3 deaths. The median LSM remained high from 20.9, 18.6, 20.4 to 20.3Kpa at week 0, 26, 52 and 78 among patients with LREs, whereas the LSM decreased from 17.8, 12.3, 10.6 to 10.2Kpa in patients without LREs respectively. Percentage changes of LSM at 26weeks from baseline were significantly associated with LREs (excluding 11 cases occurred within the first 26weeks), with a crude hazard ratio of 2.94 (95% CI: 1.73-5.00) and an albumin-adjusted hazard ratio of 2.47 (95% CI: 1.49-4.11). The Harrell C-index of these 2 models for predicting 2-year LREs were 0.68 (95% CI: 0.56-0.80) and 0.75 (95% CI: 0.65-0.85) respectively. Nomograms were developed to identify individuals at high risk for point-of-care application. ConclusionsDynamic changes of LSM alone, or combined with baseline albumin, could predict LREs in patients with HBV-related compensated cirrhosis during antiviral therapy.

基金：
National Key Technologies RD ProgramNational Key Technology R&D Program [2015BAI13B09]; Beijing Municipal Science and Technology CommissionBeijing Municipal Science & Technology Commission [D161100002716003, Z171100002217082]; Beijing Talents Fund [2016000021469G226]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类 | 2 区 医学
小类 | 2 区 胃肠肝病学
最新[2025]版：
大类 | 2 区 医学
小类 | 3 区 胃肠肝病学
JCR分区：
出版当年[2016]版：
Q1 GASTROENTEROLOGY & HEPATOLOGY
最新[2023]版：
Q1 GASTROENTEROLOGY & HEPATOLOGY

影响因子： 最新[2023版] 最新五年平均[2021-2025] 出版当年[2016版] 出版当年五年平均[2012-2016] 出版前一年[2015版] 出版后一年[2017版]

第一作者：
第一作者单位： [1]Liver Research Center, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis, National Clinical Research Center of Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构： [1]Liver Research Center, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis, National Clinical Research Center of Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, China [*1]Liver Research Center, Beijng Friendship Hospital, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Wu Shanshan,Kong Yuanyuan,Piao Hongxin,et al.On-treatment changes of liver stiffness at week 26 could predict 2-year clinical outcomes in HBV-related compensated cirrhosis[J].LIVER INTERNATIONAL.2018,38(6):1045-1054.doi:10.1111/liv.13623.
APA：
Wu, Shanshan,Kong, Yuanyuan,Piao, Hongxin,Jiang, Wei,Xie, Wen...&Jia, Jidong.(2018).On-treatment changes of liver stiffness at week 26 could predict 2-year clinical outcomes in HBV-related compensated cirrhosis.LIVER INTERNATIONAL,38,(6)
MLA：
Wu, Shanshan,et al."On-treatment changes of liver stiffness at week 26 could predict 2-year clinical outcomes in HBV-related compensated cirrhosis".LIVER INTERNATIONAL 38..6(2018):1045-1054

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