单位：[1]Department of Anesthesia, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, People’s Republic of China临床科室麻醉科麻醉科首都医科大学附属北京友谊医院[2]Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Room 4310, Charlestown, MA 02129-2060, USA[3]Massachusetts General Hospital Biostatistics Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA[4]Department of Psychiatry, Tenth People’s Hospital of Tongji University, Shanghai 200072, People’s Republic of China[5]Department of Anesthesia, Brigham & Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA[6]Divisions of General Medicine and Primary Care and Gerontology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Anesthesia/surgery could be associated with cognitive impairment and Alzheimer's disease neuropathogenesis. However, whether surgery under different anesthetics has different effects on cognitive function remains largely unknown. We therefore set out to compare effects of anesthetic isoflurane or desflurane plus surgery on cognitive function and hippocampus levels of synaptic marker (postsynaptic density-95 and synaptophysin) and ATP. Five-month-old AD Transgenic (Tg) (FAD5X) and wild-type male mice received isoflurane or desflurane plus abdominal surgery. We assessed cognitive function in Barnes maze and measured hippocampus levels of postsynaptic density-95, synaptophysin, and ATP in the mice. We determined whether vitamin K-2 could mitigate these anesthesia/surgery-induced changes. Isoflurane, but not desflurane, plus surgery increased escape latency and escape distance in Barnes maze probe test and reduced postsynaptic density-95, synaptophysin, and ATP levels as compared to control condition in AD Tg mice. Vitamin K-2 attenuated the anesthesia/surgery-induced changes in the AD Tg mice. These findings suggest that isoflurane, but not desflurane, plus surgery might induce cognitive impairment via causing brain energy deficits. Pending confirmative studies in both animals and humans suggest desflurane could be a better choice for AD patients when surgery is needed. Moreover, vitamin K-2 could treat cognitive deficiency associated with anesthesia and surgery.
基金：
National Institutes of Health, Bethesda, MDUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01GM088801, R01AG041274, R01HD086977]; National Institute on AgingUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Aging (NIA) [P01 AG031720, R01AG030618, K24AG035075, R01AG051658, R21AG048637, RO1AG051812]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81571034]; EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENTUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) [R01HD086977] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of General Medical Sciences (NIGMS) [R01GM088801] Funding Source: NIH RePORTER; NATIONAL INSTITUTE ON AGINGUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Aging (NIA) [R01AG041274, R21AG048637, R01AG030618, R01AG051658, P01AG031720, R01AG051812, K24AG035075] Funding Source: NIH RePORTER
第一作者单位：[1]Department of Anesthesia, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, People’s Republic of China[2]Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Room 4310, Charlestown, MA 02129-2060, USA
通讯作者：
推荐引用方式(GB/T 7714)：
Miao Huihui,Dong Yuanlin,Zhang Yiying,et al.Anesthetic Isoflurane or Desflurane Plus Surgery Differently Affects Cognitive Function in Alzheimer's Disease Transgenic Mice[J].MOLECULAR NEUROBIOLOGY.2018,55(7):5623-5638.doi:10.1007/s12035-017-0787-9.
APA：
Miao, Huihui,Dong, Yuanlin,Zhang, Yiying,Zheng, Hui,Shen, Yuan...&Xie, Zhongcong.(2018).Anesthetic Isoflurane or Desflurane Plus Surgery Differently Affects Cognitive Function in Alzheimer's Disease Transgenic Mice.MOLECULAR NEUROBIOLOGY,55,(7)
MLA：
Miao, Huihui,et al."Anesthetic Isoflurane or Desflurane Plus Surgery Differently Affects Cognitive Function in Alzheimer's Disease Transgenic Mice".MOLECULAR NEUROBIOLOGY 55..7(2018):5623-5638
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