It has been proved that hyperuricemia is associated with non-alcoholic fatty liver disease (NAFLD). The xanthine oxidase (XO) inhibitor, febuxostat, decreases free fatty acids-induced fat accumulation in HFDT-fed mice. Here, it is shown that febuxostat attenuates fat accumulation and reactive oxygen species (ROS) in HepG2 cells. It was further found that the underlying mechanism is related to the reduction in expression of NLRP3/caspase-1/IL-18/IL-1beta and improved insulin resistance (IR). This finding highlights the possible molecular pathways involving NLRP3 activation for management of ROS and insulin IR. In conclusion, febuxostat may be a promising potential treatment for patients with NAFLD.
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外文
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中科院(CAS)分区：
出版当年[2017]版：
大类|4 区医学
小类|4 区内分泌学与代谢4 区免疫学4 区医学：研究与实验4 区生理学
最新[2025]版：
无
JCR分区：
出版当年[2016]版：
Q3MEDICINE, RESEARCH & EXPERIMENTALQ4PHYSIOLOGYQ4IMMUNOLOGYQ4ENDOCRINOLOGY & METABOLISM
最新[2023]版：
Q4ENDOCRINOLOGY & METABOLISMQ4IMMUNOLOGYQ4MEDICINE, RESEARCH & EXPERIMENTALQ4PHYSIOLOGY
第一作者单位：[1]Cent S Univ, Xiangya Hosp, Dept Endocrinol, Changsha, Hunan, Peoples R China
通讯作者：
通讯机构：[1]Cent S Univ, Xiangya Hosp, Dept Endocrinol, Changsha, Hunan, Peoples R China[*1]Cent S Univ, Xiangya Hosp, Xiangya Rd 87, Changsha 410008, Hunan, Peoples R China
推荐引用方式(GB/T 7714)：
Tang W.,Mu J.,Chen Q. I.,et al.THE INVOLVEMENT AND MECHANISM OF FEBUXOSTAT IN NON-ALCOHOLIC FATTY LIVER DISEASE CELLS[J].JOURNAL of BIOLOGICAL REGULATORS and HOMEOSTATIC AGENTS.2018,32(3):545-551.
APA：
Tang, W.,Mu, J.,Chen, Q. I.,Li, X.&Liu, H..(2018).THE INVOLVEMENT AND MECHANISM OF FEBUXOSTAT IN NON-ALCOHOLIC FATTY LIVER DISEASE CELLS.JOURNAL of BIOLOGICAL REGULATORS and HOMEOSTATIC AGENTS,32,(3)
MLA：
Tang, W.,et al."THE INVOLVEMENT AND MECHANISM OF FEBUXOSTAT IN NON-ALCOHOLIC FATTY LIVER DISEASE CELLS".JOURNAL of BIOLOGICAL REGULATORS and HOMEOSTATIC AGENTS 32..3(2018):545-551
