详情页 - 聚合机构库演示平台

当前位置：首页 > 详情页

IL-4R alpha Polymorphism Is Associated With Myasthenia Gravis in Chinese Han Population

99| 认领 | 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

单位： [1]Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, China [2]Department of Neurology, Qilu Hospital of Shandong University, Jinan, China [3]Department of Clinical Medicine, University of Bergen, Bergen, Norway, [4]Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China [5]ICU, Affiliated Hospital of Qingdao University, Qingdao, China [6]Department of Neurology, Peking University First Hospital, Beijing, China

出处：

DOI：

ISSN：

关键词： myasthenia gravis interleukin-4 receptor polymorphism susceptibility severity

摘要：

Interleukin-4 (IL-4) is a potent growth and differentiation factor for B cells which play a vital role in the pathogenesis of myasthenia gravis (MG). IL-4 exerts its function by binding to three types of IL-4 receptor (IL-4R) complexes. IL-4R alpha is the key component of the IL-4R complex. We hypothesize that polymorphism of IL-4R alpha gene may be associated with the susceptibility and severity of MG. A Chinese cohort of 480 MG patients and 487 healthy controls were recruited. Polymorphisms of IL-4R alpha gene were determined with SNPscan (TM) methods and compared between MG and control groups, as well as among MG subgroups. Rs2107356 and rs1805010 were found to be associated with adult thymoma associated MG, and rs1801275 was found to be associated with adult non-thymoma AChR-Ab positive MG. We did not found association between IL-4R alpha polymorphism and the severity of MG. Genetic variations of IL-4R alpha were found associated with the susceptibility of MG in Chinese Han population.

基金：

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2017]版：

大类 | 2 区医学

小类 | 3 区临床神经病学 3 区神经科学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区临床神经病学 3 区神经科学

JCR分区：

出版当年[2016]版：

Q2 CLINICAL NEUROLOGY Q2 NEUROSCIENCES

最新[2023]版：

Q2 CLINICAL NEUROLOGY Q3 NEUROSCIENCES

影响因子： 最新[2023版] 2.7 最新五年平均[2021-2025] 3.3 出版当年[2016版] 3.552 出版当年五年平均[2012-2016] 0 出版前一年[2015版] 3.184 出版后一年[2017版] 3.508

第一作者：

第一作者单位： [1]Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, China

共同第一作者：

通讯作者：

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Rs3761389 polymorphism in autoimmune regulator (AIRE) gene is associated with susceptibility of myasthenia gravis in Chinese patients [2]Vitamin D Receptor Polymorphism and Myasthenia Gravis in Chinese Han Population [3]自身免疫调节因子基因多态性与重症肌无力的相关性 [4]il-17a基因rs8193037和rs1974226位点多态性与重症肌无力的相关性研究 [5]Complement C3 polymorphism is associated with the susceptibility of myasthenia gravis in Chinese adult patients [6]Association between CTLA-4 gene polymorphism and myasthenia gravis in a Chinese cohort [7]补体c3基因rs7951位点多态性与重症肌无力的相关性研究 [8]CTLA4 Variants and Haplotype Contribute Genetic Susceptibility to Myasthenia Gravis in Northern Chinese Population [9]白细胞介素4受体alpha亚单位基因多态性与重症肌无力的相关性 [10]tlr9基因rs352140位点多态性与重症肌无力的关系