单位：[1]State Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Science, Beijing University of Chemical Technology, Beijing 100029, China[2]College of Engineering and College of Dentistry, Howard University, Washington, DC 20059, United States[3]Department of Hepatobiliary Surgery, Department of Gastroenterology, China-Japan Friendship Hospital, Beijing 100029, China
Mitochondria play a key role in a variety of physiological processes, and mitochondria-targeting drug delivery is helpful and effective in cancer therapy. Rhodamine123 (Rhod123) and Doxorubicin (Dox) are not new chemical molecules, and they both can inhibit the growth of cancerous cells. Here, we combine these two "old" chemicals with polydopamine nanoparticles (PDA NPs) to strengthen the antitumor effect with the aid of near-infrared irradiation. PDA NPs carry these two chemicals tightly by hydrogen bonds and pi-pi stacking besides chemical bonds. The better antitumor profile of PDA-Rhod-Dox comes from the mitochondria-targeting delivery, which decreases ATP in living cells, causing apoptosis of cancerous cells effectively and inhibiting the growth of tumors in mice. The synergistic effect of PDA, Rhod123, and Dox improves the treatment effect of conventional chemotherapy drugs.
基金：
Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81728010, 21775010, 21575032]; Beijing Natural Science Foundation-Haidian Original Innovation Joint Fund [L172018]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [PYBZ1707, buctrc201607, PT1801]; Open Ground from Beijing National Laboratory for Molecular Sciences; Institute of Chemistry CASChinese Academy of Sciences
语种：
外文
被引次数：
WOS：
中科院(CAS)分区：
出版当年[2017]版：
大类|2 区生物
小类|2 区生化研究方法2 区生化与分子生物学2 区有机化学3 区化学综合
最新[2025]版：
大类|2 区化学
小类|2 区生化研究方法2 区有机化学3 区生化与分子生物学3 区化学：综合
JCR分区：
出版当年[2016]版：
Q1CHEMISTRY, ORGANICQ1BIOCHEMICAL RESEARCH METHODSQ1BIOCHEMISTRY & MOLECULAR BIOLOGYQ1CHEMISTRY, MULTIDISCIPLINARY
最新[2023]版：
Q1BIOCHEMICAL RESEARCH METHODSQ1CHEMISTRY, ORGANICQ2BIOCHEMISTRY & MOLECULAR BIOLOGYQ2CHEMISTRY, MULTIDISCIPLINARY
第一作者单位：[1]State Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Science, Beijing University of Chemical Technology, Beijing 100029, China
通讯作者：
推荐引用方式(GB/T 7714)：
Wang Zhuo,Chen Yuzhi,Zhang Hui,et al.Mitochondria-Targeting Polydopamine Nanocomposites as Chemophotothermal Therapeutics for Cancer[J].BIOCONJUGATE CHEMISTRY.2018,29(7):2415-2425.doi:10.1021/acs.bioconjchem.8b00325.
APA：
Wang, Zhuo,Chen, Yuzhi,Zhang, Hui,Li, Yawen,Ma, Yufan...&Zhang, Xin.(2018).Mitochondria-Targeting Polydopamine Nanocomposites as Chemophotothermal Therapeutics for Cancer.BIOCONJUGATE CHEMISTRY,29,(7)
MLA：
Wang, Zhuo,et al."Mitochondria-Targeting Polydopamine Nanocomposites as Chemophotothermal Therapeutics for Cancer".BIOCONJUGATE CHEMISTRY 29..7(2018):2415-2425
