单位：[1]Department of Neurosurgery, China-Japan Friendship Hospital, Beijing, China[2]Department of Spine Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China[3]Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA[4]Johns Hopkins Hospital, Zayed Tower, Suite 6115F, 1800 Orleans Street, Baltimore, MD 21287, USA
IntroductionSpinal high-grade gliomas (S-HGGs) is an extremely rare entity in the literature, with only sporadic cases reported. We aim to characterize prognostic factors for post-treatment survival using the SEER database.MethodsWe examined all patients with gliomas located in the spinal cord. WHO-grade was first determined by site-specific factor-1 (WHO-grade), then supplemented by direct review of ICD-O-3 histology. Only grades 3 and 4 were included in this study. Multivariable Cox regression analysis was performed.ResultsA total of 158 high-grade spinal cord gliomas were included. Mean age at diagnosis was 36.88years with 52.8% male. Median survival of all patients was 20months. A stepwise Akaike information criterion was performed for multivariable Cox regression, with forced inclusion of surgery extent and postoperative radiation therapy (RT). The final model selection added tumor size in addition to these two variables. Tumor size was not related to survival in our study. The extend of surgery had no significant impact on survival of patients, whereas postoperative RT is associated with prolonged survival (HR=0.55, CI [0.33, 0.93], p=0.026).ConclusionS-HGGs are rare tumors with aggressive course of disease. We have found that overall median survival of S-HGGs is poor at 24 months, and no demographic or tumor-related factors have been confirmed. Extend of surgery is not associated with improved survival after adjusting for postoperative RT. Postoperative RT is the only factor in our study associated with prolonged survival in S-HGGs.
第一作者单位：[1]Department of Neurosurgery, China-Japan Friendship Hospital, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[3]Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA[4]Johns Hopkins Hospital, Zayed Tower, Suite 6115F, 1800 Orleans Street, Baltimore, MD 21287, USA
推荐引用方式(GB/T 7714)：
Jiang Liu,Minghui Zheng,Wuyang Yang,et al.Impact of surgery and radiation therapy on spinal high-grade gliomas: a population-based study[J].JOURNAL of NEURO-ONCOLOGY.2018,139(3):609-616.doi:10.1007/s11060-018-2904-7.
APA：
Jiang Liu,Minghui Zheng,Wuyang Yang,Sheng‑fu L. Lo&Judy Huang.(2018).Impact of surgery and radiation therapy on spinal high-grade gliomas: a population-based study.JOURNAL of NEURO-ONCOLOGY,139,(3)
MLA：
Jiang Liu,et al."Impact of surgery and radiation therapy on spinal high-grade gliomas: a population-based study".JOURNAL of NEURO-ONCOLOGY 139..3(2018):609-616
