Aim: We aim to identify the key long noncoding RNAs (lncRNAs) in early-stage colon adenocarcinoma (COAD). Patients & methods: Compared with colonic intraepithelial neoplasia, differentially expressed lncRNAs (DElncRNAs) in early-stage COAD were obtained by RNA-sequencing. Our previous work has obtained the differentially expressed mRNAs and miRNAs (DEmRNAs and DEmiRNAs) in early-stage COAD. DEmiRNA-DElncRNA-DEmRNA interaction analysis and functional annotation were performed. Validation of expression and receiver-operating characteristic analyses were performed based on The Cancer Genome Atlas. Results: Seventy-nine significantly DElncRNAs in early-stage COAD were obtained. MiR153-3p-TUG1-DAPK1/ARNT2/KLK3/PLD1/SMAD2 and miR-153-3p-SNHG17-COL11A1/IGFBP3/KLF6 interactions were associated with early-stage COAD. Five DElncRNAs (ELFN1-AS1, LINC01234, SNHG17, UCA1 and LOC101929549) involved in early-stage COAD with potential diagnostic value. Conclusion: LncRNAs involve in early-stage COAD by interaction with COAD-regulated genes and miRNAs.
第一作者单位：[1]Department of Gastroenterology, China-Japan Friendship Hospital, Beijing 100029, PR China
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推荐引用方式(GB/T 7714)：
Liu JiXi,Li Wen,Li JingTao,et al.Screening key long non-coding RNAs in early-stage colon adenocarcinoma by RNA-sequencing[J].EPIGENOMICS.2018,10(9):1215-1228.doi:10.2217/epi-2017-0155.
APA：
Liu, JiXi,Li, Wen,Li, JingTao,Liu, Fang&Zhou, Lei.(2018).Screening key long non-coding RNAs in early-stage colon adenocarcinoma by RNA-sequencing.EPIGENOMICS,10,(9)
MLA：
Liu, JiXi,et al."Screening key long non-coding RNAs in early-stage colon adenocarcinoma by RNA-sequencing".EPIGENOMICS 10..9(2018):1215-1228
