单位:[1]1Liver Transplantation Center, National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, China临床科室国家中心普外分中心普外四科(肝脏移植外科)首都医科大学附属北京友谊医院[2]Department of Hepatobiliary and Pancreatic Surgery, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi, China[3]Beijing Key Laboratory of Tolerance Induction and Organ Protection in Transplantation, Beijing Friendship Hospital, Capital Medical University, Beijing, China首都医科大学附属北京友谊医院
Objectives: This study aimed to investigate the outcomes of adult liver transplant procedures using grafts from pediatric donors after circulatory death. Materials and Methods: We retrospectively analyzed the data of 19 pediatric-to-adult liver transplant procedures from July 2013 to May 2016 in our hospital. Nineteen adult liver transplant procedures were performed using livers from pediatric donors after circulatory death. Results: We performed 18 orthotopic and 1 piggyback liver transplant procedure. The median graft-torecipient weight ratio was 1.26% (range, 0.86% to 2.46%). The median warm and cold ischemia times were 11 minutes (range, 8-20 min) and 638 minutes (range, 200-843 min), respectively. Complications after the operation included postoperative pulmonary infection (8 patients), fungal infection (1 patient), cytomegalovirus infection (1 patient), hepatic artery thrombosis and biliary stricture (1 patient), portal vein stenosis (1 patient), and graft failure (2 patients). For patients with graft failure, 1 patient received retransplant and 1 died. The patients were followed for 22.44 months (range, 9.63-44.07 mo) after transplant and showed normal liver function and good health. The 3-year survival rates of grafts and patients were 89.47% and 94.74%, respectively. Conclusions: Appropriate evaluation of donors and recipients and accurate intraoperative and post operative treatment can ensure successful application of livers from pediatric donors after circulatory death in adult recipients.
基金:
Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support [XMLX201302]; Capital Special Program for Health Research and Development [2016-1-2021]
第一作者单位:[1]1Liver Transplantation Center, National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, China[2]Department of Hepatobiliary and Pancreatic Surgery, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi, China
通讯作者:
通讯机构:[1]1Liver Transplantation Center, National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, China[3]Beijing Key Laboratory of Tolerance Induction and Organ Protection in Transplantation, Beijing Friendship Hospital, Capital Medical University, Beijing, China[*1]Department of Liver Transplantation, Beijing Friendship Hospital Affiliated to Capital Medical University, No. 95 Yongan Road, Beijing 100050, China
推荐引用方式(GB/T 7714):
Zhang Rui,Zhu Zhi-Jun,Sun Li-Ying.Application of Pediatric Donor Livers After Circulatory Death in Adult Liver Transplantation: A Single-Center Experience[J].EXPERIMENTAL and CLINICAL TRANSPLANTATION.2018,16(5):575-581.doi:10.6002/ect.2017.0358.
APA:
Zhang, Rui,Zhu, Zhi-Jun&Sun, Li-Ying.(2018).Application of Pediatric Donor Livers After Circulatory Death in Adult Liver Transplantation: A Single-Center Experience.EXPERIMENTAL and CLINICAL TRANSPLANTATION,16,(5)
MLA:
Zhang, Rui,et al."Application of Pediatric Donor Livers After Circulatory Death in Adult Liver Transplantation: A Single-Center Experience".EXPERIMENTAL and CLINICAL TRANSPLANTATION 16..5(2018):575-581