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Application of Pediatric Donor Livers After Circulatory Death in Adult Liver Transplantation: A Single-Center Experience

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单位: [1]1Liver Transplantation Center, National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, China [2]Department of Hepatobiliary and Pancreatic Surgery, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi, China [3]Beijing Key Laboratory of Tolerance Induction and Organ Protection in Transplantation, Beijing Friendship Hospital, Capital Medical University, Beijing, China
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关键词: Donation after circulatory death Liver volume Small-for-size syndrome

摘要:
Objectives: This study aimed to investigate the outcomes of adult liver transplant procedures using grafts from pediatric donors after circulatory death. Materials and Methods: We retrospectively analyzed the data of 19 pediatric-to-adult liver transplant procedures from July 2013 to May 2016 in our hospital. Nineteen adult liver transplant procedures were performed using livers from pediatric donors after circulatory death. Results: We performed 18 orthotopic and 1 piggyback liver transplant procedure. The median graft-torecipient weight ratio was 1.26% (range, 0.86% to 2.46%). The median warm and cold ischemia times were 11 minutes (range, 8-20 min) and 638 minutes (range, 200-843 min), respectively. Complications after the operation included postoperative pulmonary infection (8 patients), fungal infection (1 patient), cytomegalovirus infection (1 patient), hepatic artery thrombosis and biliary stricture (1 patient), portal vein stenosis (1 patient), and graft failure (2 patients). For patients with graft failure, 1 patient received retransplant and 1 died. The patients were followed for 22.44 months (range, 9.63-44.07 mo) after transplant and showed normal liver function and good health. The 3-year survival rates of grafts and patients were 89.47% and 94.74%, respectively. Conclusions: Appropriate evaluation of donors and recipients and accurate intraoperative and post operative treatment can ensure successful application of livers from pediatric donors after circulatory death in adult recipients.

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出版当年[2017]版:
大类 | 4 区 医学
小类 | 4 区 移植
最新[2025]版:
大类 | 4 区 医学
小类 | 4 区 移植
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出版当年[2016]版:
Q4 TRANSPLANTATION
最新[2023]版:
Q4 TRANSPLANTATION

影响因子: 最新[2023版] 最新五年平均[2021-2025] 出版当年[2016版] 出版当年五年平均[2012-2016] 出版前一年[2015版] 出版后一年[2017版]

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第一作者单位: [1]1Liver Transplantation Center, National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, China [2]Department of Hepatobiliary and Pancreatic Surgery, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi, China
通讯作者:
通讯机构: [1]1Liver Transplantation Center, National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, China [3]Beijing Key Laboratory of Tolerance Induction and Organ Protection in Transplantation, Beijing Friendship Hospital, Capital Medical University, Beijing, China [*1]Department of Liver Transplantation, Beijing Friendship Hospital Affiliated to Capital Medical University, No. 95 Yongan Road, Beijing 100050, China
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