单位：[1]Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, China[2]National Clinical Research Center for Respiratory Diseases, Beijing, China
Objective: To investigate the relationship between exhaled NO and vascular endothelial growth factor (VEGF) expression in bronchial asthma patients with asthma severity and airway inflammation. Methods: From January 2015 to December 2017, 260 patients with bronchial asthma diagnosed in our hospital were enrolled. The expression of VEGF in the induced sputum was measured by enzyme-linked immunosorbent assay (ELISA) in the control (n=260) and asthma groups (n=260) in the same period. The NO concentration was measured on the same day. Results: Intercellular adhesion molecule-1 (ICAM-1), VEGF, tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) levels were significantly elevated in sputum of patients with acute asthma, and the concentration in exhaled NO of all patients was also significantly higher than the control group and the stable phase of asthma. The expression of ICAM-1, VEGF, TNF-alpha and IL-6 was significantly elevated in patients with severe asthma. There were significant differences in patients with mild to moderate asthma (P<0.05). Correlation analysis showed that VEGF, IL-6 and TNF-alpha were positively correlated with the degree of asthma (P<0.05), but negatively correlated with FEV1.0, FEV1.0/FVC% and PEF (P<0.05). Conclusion: The expression of VEGF in sputum in patients with bronchial asthma is closely related to the severity of asthma and airway inflammation.
第一作者单位：[1]Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, China[2]National Clinical Research Center for Respiratory Diseases, Beijing, China[*1]Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital,National Clinical Research Center for Respiratory Diseases, 2 East Yinghua Road, Chaoyang District, Beijing 100029, China.
通讯作者：
通讯机构：[1]Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, China[2]National Clinical Research Center for Respiratory Diseases, Beijing, China[*1]Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital,National Clinical Research Center for Respiratory Diseases, 2 East Yinghua Road, Chaoyang District, Beijing 100029, China.
推荐引用方式(GB/T 7714)：
Yongming Zhang,Jiangtao Lin,Zhencui Ren,et al.Predictive effect of exhaled NO and VEGF expression levels on the severity of bronchial asthma and airway inflammation[J].INTERNATIONAL JOURNAL of CLINICAL and EXPERIMENTAL PATHOLOGY.2018,11(11):5401-5406.
APA：
Yongming Zhang,Jiangtao Lin,Zhencui Ren&Xiaopan Li.(2018).Predictive effect of exhaled NO and VEGF expression levels on the severity of bronchial asthma and airway inflammation.INTERNATIONAL JOURNAL of CLINICAL and EXPERIMENTAL PATHOLOGY,11,(11)
MLA：
Yongming Zhang,et al."Predictive effect of exhaled NO and VEGF expression levels on the severity of bronchial asthma and airway inflammation".INTERNATIONAL JOURNAL of CLINICAL and EXPERIMENTAL PATHOLOGY 11..11(2018):5401-5406
