单位：[1]Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China[2]Department of Radiology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 211100, China[3]School of Computer Science and Engineering, Southeast University, Nanjing 210018, China[4]Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100071, China医技科室影像中心放射科首都医科大学附属北京友谊医院[5]Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510275, China中山大学附属第二医院
Background: Previous studies have demonstrated that cognitive impairment is linked with neurophysiological alterations in chronic tinnitus. This study aimed to investigate the intrinsic functional connectivity (FC) pattern within the default mode network (MN) and its associations with cognitive impairment in tinnitus patients using a resting-state functional magnetic resonance imaging (rs-fMRI). Methods: Thirty-five chronic unilateral tinnitus patients, and 50 healthy controls were recruited for rsfMRI scanning. Both groups were age, gender and education level well-matched. The posterior cingulate cortex (PCC) was chosen as the region of interest (ROI) for detecting the FC changes, and determining if these abnormalities were related to a specific cognitive performance and tinnitus characteristic. Results: Relative to the healthy controls, tinnitus patients showed increased FC between the PCC and the right medial prefrontal cortex (mPFC). Moreover, the enhanced FC between the PCC and right mPFC was correlated with the poorer TMT-B scores (r=0.474, P=0.008). These correlations were adjusted by age, gender, education level, GM volume, and mean hearing thresholds. The enhanced FC was not correlated with other tinnitus characteristics or cognitive performances. Conclusions: The enhanced FC pattern of the PCC that is correlated with cognitive impairment in chronic tinnitus patients, especially the executive dysfunction. Enhanced connectivity pattern within the DMN may play a crucial role in neurophysiological mechanism in tinnitus patients with cognitive dysfunction.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81601477]; Youth Medical Talents of Jiangsu Province [QNRC2016062]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2017M610337]; Jiangsu Postdoctoral Science FoundationChina Postdoctoral Science Foundation [1701007A]; Nanjing Outstanding Youth Fund [JQX17006]
第一作者单位：[1]Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China
通讯作者：
通讯机构：[1]Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China[2]Department of Radiology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 211100, China[*1]Department of Radiology, The Affiliated Jiangning Hospital of Nanjing Medical University, No.168 Gushan Road, Nanjing 211100, China[*2]Department of Radiology, Nanjing First Hospital, Nanjing Medical University, No.68, Changle Road, Nanjing 210006, China
推荐引用方式(GB/T 7714)：
Chen Yu-Chen,Zhang Hong,Kong Youyong,et al.Alterations of the default mode network and cognitive impairment in patients with unilateral chronic tinnitus[J].QUANTITATIVE IMAGING in MEDICINE and SURGERY.2018,8(10):1020-1029.doi:10.21037/qims.2018.11.04.
APA：
Chen, Yu-Chen,Zhang, Hong,Kong, Youyong,Lv, Han,Cai, Yuexin...&Yin, Xindao.(2018).Alterations of the default mode network and cognitive impairment in patients with unilateral chronic tinnitus.QUANTITATIVE IMAGING in MEDICINE and SURGERY,8,(10)
MLA：
Chen, Yu-Chen,et al."Alterations of the default mode network and cognitive impairment in patients with unilateral chronic tinnitus".QUANTITATIVE IMAGING in MEDICINE and SURGERY 8..10(2018):1020-1029
