单位：[1]Department of Gastroenterology and Hepatology, Beijing You'an Hospital, Capital Medical University, Center for Collaborative Innovation in Critical Infectious Diseases, Beijing, China.[2]Department of Emergency, Beijing Friendship Hospital, Capital Medical University, Beijing, China.临床科室急危重症及感染医学中心急诊医学科首都医科大学附属北京友谊医院[3]Department of Pathology, Beijing You'an Hospital, Capital Medical University, Beijing, China.[4]Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.[5]Department of Medicine II, Section Molecular Hepatology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Aim. To evaluate the diagnostic value of dynamic contrast-enhanced computed tomography (CT) and magnetic resonance imaging (MRI) in the differential diagnosis of hepatic angiomyolipoma (HAML) and hepatocellular carcinoma (HCC) and to clarify the relationship between histopathological features and CT or MRI imaging performances in HAML. Material and methods. Six HAML and 33 non-cirrhotic HCC patients confirmed by histopathology were retrospectively analyzed. The serum biomarkers, CT and MRI examinations were conventionally performed before the confirmatory histological diagnosis. The clinical data from their medical records was also analyzed. Results. Six HAML patients were annotated as two types according to CT and MRI imaging characteristics, including hypovascular type (n = 1) and hypervascular type (n = 5). The imaging performances of the 33 HCC patients were hypervascular type. Moreover, all the 5 hypervascular type HAML patients were misdiagnosed as HCC by CT or MRI. We also found that the hypervascular type of HAML patients contained more vessels and less fatty tissues in histopathology than hypovascular type of HAML patients. However, the clinical features included HCC high risk factors (hepatitis B or C), non-specific symptoms, male and increased serum alpha fetoprotein (AFP) were more common in HCC patients than HAML patients (P < 0.05, respectively). Conclusions. The CT or MRI imaging performances of HAML patients containing more vessels and less fatty tissues in histopathology resemble the imaging performance of HCC patients. These clinical features may be of great help in the differential diagnosis in the current clinical practices.
基金：
Capital Science and Technology Development Fund [2014-1-2181]; Beijing Municipal Administration of Hospitals' Clinical medicine Development of special funding [ZYLX2016-10]; Beijing Municipal Administration of Hospitals' Ascent Plan [DFL20151602]; National Natural Science FoundationNational Natural Science Foundation of China (NSFC) [81672725]
第一作者单位：[1]Department of Gastroenterology and Hepatology, Beijing You'an Hospital, Capital Medical University, Center for Collaborative Innovation in Critical Infectious Diseases, Beijing, China.[2]Department of Emergency, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
通讯作者：
通讯机构：[1]Department of Gastroenterology and Hepatology, Beijing You'an Hospital, Capital Medical University, Center for Collaborative Innovation in Critical Infectious Diseases, Beijing, China.[*1]Department of Gastroenterology and Hepatology, Beijing You'an Hospital, Capital Medical University, Fengtai District, Beijing 10069, China.
推荐引用方式(GB/T 7714)：
Hongtao Wei,Hui Liu,Yuhan Chen,et al.The Histopathological Features and CT/MRI Imaging Performances in Hepatic Angiomyolipoma Patients[J].ANNALS of HEPATOLOGY.2017,16(5):759-764.doi:10.5604/01.3001.0010.2769.
APA：
Hongtao Wei,Hui Liu,Yuhan Chen,Xiaowei Xue,Honglei Weng&Huiguo Ding.(2017).The Histopathological Features and CT/MRI Imaging Performances in Hepatic Angiomyolipoma Patients.ANNALS of HEPATOLOGY,16,(5)
MLA：
Hongtao Wei,et al."The Histopathological Features and CT/MRI Imaging Performances in Hepatic Angiomyolipoma Patients".ANNALS of HEPATOLOGY 16..5(2017):759-764
