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Application of reflectance confocal microscopy to evaluate skin damage after irradiation with an yttrium-scandium-gallium-garnet (YSGG) laser

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收录情况： ◇ SCIE

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单位： [1]Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, 95 Yong An Road, Xi Cheng District, Beijing 100050, People’s Republic of China [2]Department of Dermatology, Beijing Tian Tan Hospital, Capital Medical University, Beijing 100050, People’s Republic of China [3]Department of Dermatology, Peking Union Medical College Hospital, No.1 Shuaifuyuan, Dong Cheng District, Beijing 100730, People’s Republic of China

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关键词： Reflectance confocal microscopy Yttrium-scandium-gallium-garnet laser Micro ablative columns Microscopic treatment zones Thermal coagulation zone

摘要：

The objective of this study was to observe the characteristics of the skin after irradiation with a 2790-nm yttrium-scandium-gallium-garnet (YSGG) laser using reflectance confocal microscopy (RCM). A 2790-nm YSGG laser was used to irradiate fresh foreskin (four doses, at spot density 3) in vitro. The characteristics of microscopic ablative columns (MAC), thermal coagulation zone (TCZ), and microscopic treatment zones (MTZ) were observed immediately after irradiation using digital microscope and RCM. The characteristics of MAC, TCZ, and MTZ with variations in pulse energy were comparatively analyzed. After irradiation, MAC, TCZ, and MTZ characteristics and undamaged skin between MTZs can be observed by RCM. The depth and width of MTZ obviously increased with the increase in pulse energy. At 80, 120, and 160 mJ/microbeam (MB), the MTZ actual area and proportion were about two times that of the theoretical value and three times at 200 mJ/MB. With increases in depth, the single MAC gradually decreased in a fingertip-shaped model, with TCZ slowly increasing, and MTZ slightly decreasing in a columnar shape. RCM was able to determine the characteristics of thermal injury on the skin after the 2790-nm YSGG laser irradiation with different pulse energies. Pulse energy higher than 200 mJ/MB may have much larger thermal injury and side effect. RCM could be used in the clinic in future.

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出版当年[2016]版：

大类 | 3 区医学

小类 | 3 区工程：生物医学 3 区外科

最新[2025]版：

大类 | 4 区医学

小类 | 4 区工程：生物医学 4 区外科

JCR分区：

出版当年[2015]版：

Q2 ENGINEERING, BIOMEDICAL Q2 SURGERY

最新[2023]版：

Q2 SURGERY Q3 ENGINEERING, BIOMEDICAL

影响因子： 最新[2023版] 2.1 最新五年平均[2021-2025] 2.4 出版当年[2015版] 2.461 出版当年五年平均[2011-2015] 2.702 出版前一年[2014版] 2.489 出版后一年[2016版] 2.299

第一作者：

第一作者单位： [1]Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, 95 Yong An Road, Xi Cheng District, Beijing 100050, People’s Republic of China [2]Department of Dermatology, Beijing Tian Tan Hospital, Capital Medical University, Beijing 100050, People’s Republic of China

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