单位：[1]State Key Laboratory of Oral Diseases, Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China[2]University of Maryland Dental School, Baltimore, MD 21201, USA[3]Department of Stomatology, China-Japan Friendship Hospital, Beijing 100029, China
Induced pluripotent stem cells (iPSCs), reprogrammed from adult somatic cells using defined transcription factors, are regarded as a promising cell source for tissue engineering. For the purpose of bone tissue regeneration, efficient in vitro differentiation of iPSCs into downstream cells, such as mesenchymal stem cells (MSCs), osteoblasts, or osteocyte-like cells, before use is necessary to limit undesired tumorogenesis associated with the pluripotency of iPSCs. Until recently numerous techniques on the production of iPSC-derived osteogenic progenitors have been introduced. We reviewed these protocols and provided a perspective on the comparisons of osteogenic potentials of (1) iPSC-derived osteogenic cells produced by different protocols, (2) iPSCs from different somatic origins, and (3) iPSC-derived MSC-like cells and bone marrow stem cells. Finally, we discussed the potential application of the diseased iPSCs for systematic bone disorders.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81401794, 81000789]
第一作者单位：[1]State Key Laboratory of Oral Diseases, Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China
通讯作者：
通讯机构：[1]State Key Laboratory of Oral Diseases, Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China[2]University of Maryland Dental School, Baltimore, MD 21201, USA[*1]State Key Laboratory of Oral Diseases, Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China[*2]University of Maryland Dental School, Baltimore, MD 21201, USA
推荐引用方式(GB/T 7714)：
Wu Qingqing,Yang Bo,Hu Kevin,et al.Deriving Osteogenic Cells from Induced Pluripotent Stem Cells for Bone Tissue Engineering[J].TISSUE ENGINEERING PART B-REVIEWS.2017,23(1):1-8.doi:10.1089/ten.teb.2015.0559.
APA：
Wu, Qingqing,Yang, Bo,Hu, Kevin,Cao, Cong,Man, Yi&Wang, Ping.(2017).Deriving Osteogenic Cells from Induced Pluripotent Stem Cells for Bone Tissue Engineering.TISSUE ENGINEERING PART B-REVIEWS,23,(1)
MLA：
Wu, Qingqing,et al."Deriving Osteogenic Cells from Induced Pluripotent Stem Cells for Bone Tissue Engineering".TISSUE ENGINEERING PART B-REVIEWS 23..1(2017):1-8
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