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Molecular mechanism of smurf2 in regulating the expression of SnoN in diabetic nephropathy

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收录情况： ◇ SCIE

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单位： [1]Department of Nephrology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China [2]Department of Infectious Disease, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China

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关键词： diabetic nephropathy Ski-related novel protein N Smad ubiquitination regulatory factor 2 transforming growth factor-beta 1/small mothers against decapentaplegic signaling pathway NRK-52E ubiquitination

摘要：

The aim of the present study was to examine the regulatory mechanism underlying the depression in Ski-related novel protein N (SnoN) in diabetic nephrology (DN). NRK-52E cells, a rat primary renal tubular epithelial cell line, were cultured to clarify the effect of small mothers against decapentaplegic (Smad) ubiquitination regulatory factor 2 (smurf2) on SnoN in a low glucose environment in vitro. NRK-52E cells and DM rats were injected with adenoviruses AD-smurf2 and AD-shsmurf2, respectively, and the protein expression profiles of SnoN, smurf2 and phosphorylated (p)-Smad2 were then detected. In addition, the protein levels of smurf2, p-Smad2 and SnoN were analyzed following treatment with transforming growth factor (TGF)-beta 1 or TGF-beta 1 inhibitor to validate the effect of the TGF-beta 1/Smad signaling pathway. The effect of smurf2 on the degradation of SnoN by ubiquitination was found to be a key factor in DN, which was mediated by the TGF-beta 1/Smad signaling pathway.

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出版当年[2016]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验 4 区肿瘤学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验 4 区肿瘤学

JCR分区：

出版当年[2015]版：

Q3 MEDICINE, RESEARCH & EXPERIMENTAL Q4 ONCOLOGY

最新[2023]版：

Q2 MEDICINE, RESEARCH & EXPERIMENTAL Q2 ONCOLOGY

影响因子： 最新[2023版] 3.4 最新五年平均[2021-2025] 3 出版当年[2015版] 1.559 出版当年五年平均[2011-2015] 1.617 出版前一年[2014版] 1.554 出版后一年[2016版] 1.692

第一作者：

第一作者单位： [1]Department of Nephrology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China

通讯作者：

通讯机构： [1]Department of Nephrology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China [*1]Department of Nephrology, Beijing Friendship Hospital, Capital Medical University, 95 Yong‑An Road, Beijing 100050, P.R. China

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