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Observational Registry of Basal Insulin Treatment (ORBIT) in patients with type 2 diabetes uncontrolled with oral antihyperglycaemic drugs: Real-life use of basal insulin in China

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单位: [1]Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, China [2]The George Institute for Global Health at Peking University Health Science Center, Beijing, China [3]Department of Endocrinology, Chinese PLA General Hospital, Beijing, China [4]Department of Endocrinology, Peking University First Hospital, Beijing, China [5]Department of Endocrinology and Metabolism, Shanghai Sixth Hospital, Shanghai, China [6]Department of Endocrinology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China [7]Department of Endocrinology, China-Japan Friendship Hospital, Beijing, China [8]Department of Endocrinology, The Second Military Medical University, Shanghai, China [9]Department of Endocrinology and Metabolism, Xiangya Second Hospital, Changsha, China [10]Barbara Davis Center for Diabetes, University of Colorado Denver, Denver, Colorado
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关键词: basal insulin observational study type 2 diabetes

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Aims: To examine treatment patterns following basal insulin (BI) introduction in type 2 diabetes mellitus (T2DM) patients under real-world conditions across China. Materials and methods: Overall, 18 995 patients inadequately controlled (HbA1c >= 53 mmol/mol [7%]) with oral antihyperglycaemic drugs (OADs) and willing to receive BI treatment were registered at 209 hospitals and followed at baseline (visit 1), 3 months (visit 2) and 6 months (visit 3). Type of BI was initiated at physicians' discretion. Results: Retention with BI therapy at 6 months was 75.6%. Use of long-acting BI predominated, with insulin glargine accounting for 71%, detemir 13% and Neutral Protamine Hagedorn (NPH) insulin 16%. Over 70% of long-acting users maintained the same initial BI at visit 3, while 40% of NPH users switched treatment and 24.4% of participants initiated BI with prandial insulin. The initial mean (+/- SD) dose of BI and total insulin was 0.18 +/- 0.07 and 0.25 +/- 0.19 IU/kg, respectively, with a mean increase of daily dose by 0.03 and 0.02 IU/kg after 6 months, respectively. Only 56.6% of insulin users reported dose titration at visit 3. Mean HbA1c was 81 mmol/mol (9.6%) at baseline and 57 mmol/mol (7.4%) at 6 months. The frequency of hypoglycaemia was 1.61 and 2.07 episodes/patient-year at baseline and 6 months, respectively. Conclusions: In real-world clinical settings, add-on BI therapy in T2DM patients is associated with significant improvement in glycaemic control without overtly compromising safety related to hypoglycaemia and weight gain. Evolution of insulin treatment regimens varied among patients, but dose titration was suboptimal. More active BI dose titration might further improve glycaemic outcome in patients receiving BI therapy.

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出版当年[2016]版:
大类 | 1 区 医学
小类 | 2 区 内分泌学与代谢
最新[2025]版:
大类 | 2 区 医学
小类 | 2 区 内分泌学与代谢
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出版当年[2015]版:
Q1 ENDOCRINOLOGY & METABOLISM
最新[2023]版:
Q1 ENDOCRINOLOGY & METABOLISM

影响因子: 最新[2023版] 最新五年平均[2021-2025] 出版当年[2015版] 出版当年五年平均[2011-2015] 出版前一年[2014版] 出版后一年[2016版]

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第一作者单位: [1]Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, China [2]The George Institute for Global Health at Peking University Health Science Center, Beijing, China [*1]Department of Endocrinology and Metabolism, Peking University People’s Hospital, No. 11, Xizhimen Nan Da Jie, Xicheng District, Beijing 100044, P.R. China.
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通讯机构: [1]Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, China [2]The George Institute for Global Health at Peking University Health Science Center, Beijing, China [10]Barbara Davis Center for Diabetes, University of Colorado Denver, Denver, Colorado [*1]Department of Endocrinology and Metabolism, Peking University People’s Hospital, No. 11, Xizhimen Nan Da Jie, Xicheng District, Beijing 100044, P.R. China. [*2]Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, 1775 Aurora Court, Aurora, Denver, Colorado 80045.
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